RG108 CAS NO.48208-26-0

Product Name:    RG108
Synonyms:    (S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;RG108/RG-108;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;N-Phthaloyl-L-tryptophan;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-;N-Phthaloyl-L-tryptophan (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;CS-1518;DNA Methyltransferase Inhibitor                       
CAS:    48208-26-0                               
MF:    C19H14N2O4                
MW:    334.33                     
Mol File:    48208-26-0.mol                                                                        
           

Melting point     192-194℃
Boiling point     606.0±50.0 °C(Predicted)
density     1.502±0.06 g/cm3(Predicted)
storage temp.     -20°C
solubility     DMSO: >10mg/mL
pka    3.62±0.10(Predicted)
form     powder
color     yellow
Sensitive     Light Sensitive
CAS DataBase Reference    48208-26-0
Safety Information
WGK Germany     3
MSDS Information
RG108 Usage And Synthesis
Uses    DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.
Biological Activity    Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.