Eplerenone CAS NO.107724-20-9

Product Name:    Eplerenone
Synonyms:    plerenone;(2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 4a,6a-diMethyl-2,4'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate;Eplerenone [USAN];HSDB 7522;Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-;Eplerenone intermediate Eplerenone;(7α,11α,17α)-9,11-epoxy-17-hydroxy-3-oxo-γ-lactone-pregn-4-ene-7,21-dicarboxylic acid-7-methyl ester;Eplerenone for system suitability
CAS:    107724-20-9
MF:    C24H30O6
MW:    414.49
EINECS:    600-850-8
Product Categories:    Cardiovascular APIs;Inspra;Antihypertensive;Chiral Reagents;Intermediates & Fine Chemicals;Steroid and Hormone;Pharmaceuticals;Steroids
Mol File:    107724-20-9.mol

Melting point     241-243°C
alpha     D +5° (c = 0.437 in chloroform)
Boiling point     597.9±50.0 °C(Predicted)
density     1.31±0.1 g/cm3(Predicted)
storage temp.     Store at RT
solubility     DMSO: soluble2mg/mL, clear (warmed)
form     powder
color     white to beige
λmax    240nm(lit.)
Merck     14,3625
InChIKey    UZZAHAKTLYRDOK-MGIDJNSKSA-N
Safety Information
RIDADR     3077
WGK Germany     3
HS Code     29322090
Hazardous Substances Data    107724-20-9(Hazardous Substances Data)

Description    Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
Pharmacodynamics    Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.
Biological activity    Eplerenone belongs to a class of drugs called aldosterone antagonists. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Eplerenone works by interfering with the activity of a steroid in your body called aldosterone. Aldosterone acts to increase the amount of sodium and water you retain. This increased sodium and water can cause high blood pressure, which can in turn cause heart failure.