3-Ketomorpholine CAS NO.109-11-5

Product Name:    morpholin-3-one
Synonyms:    Morpholin-3-on;3-Oxomorpholine;MORPHOLIN-3-ONE;morpholine-3-one;3-morpholone;3-MORPHOLINONE;3-Ketomorpholine;Morpholin-3-one ,98%
CAS:    109-11-5
MF:    C4H7NO2
MW:    101.1
EINECS:    203-647-9
Product Categories:    Heterocycles;Heterocycles series
Mol File:    109-11-5.mol                     

Melting point     103.0 to 107.0 °C
Boiling point     142°C/7mmHg(lit.)
density     1.122±0.06 g/cm3(Predicted)
storage temp.     Inert atmosphere,Room Temperature
pka    14.37±0.20(Predicted)
CAS DataBase Reference    109-11-5(CAS DataBase Reference)
EPA Substance Registry System    3-Morpholinone (109-11-5)

Description    3-ketomorpholine is also known as morpholin-3-one. It is useful pharmacological intermediate. Recent studies have shown that some morpholin-3-one derivatives could effectively cause cell cycle arrest at G1 phase, increase the levels of P53 and Fas, and induce A549 cell apoptosis in lung cancer. This indicates it might be a useful tool for elucidating the molecular mechanism of lung cancer cell apoptosis and might also be potential anti-cancer drugs. Some of its derivatives have been proven to be useful for the prevention and treatment of arteriosclerosis and hypertriglyceridemia.
References    He, Q., et al. "Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells." Bioorganic & Medicinal Chemistry 15.11(2007): 3889.
Murai, Hiromu, et al. "Morpholinone derivatives and method of use." US, US4237132. 1980.
Gonzalez-garcia, Maria Rosario, and Fernandez, Maria Carmen. "Morpholinyl derivatives useful as MOGAT-2 inhibitors." (2015).