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Rimegepant sulfate CAS NO.1374024-48-2
- Min.Order: 1 Milligram
- Payment Terms: T/T
- Product Details
Keywords
- Rimegepant sulfate
- 1374024-48-2
- 99%
Quick Details
- ProName: Rimegepant sulfate
- CasNo: 1374024-48-2
- Molecular Formula: C28H30F2N6O7S
- Appearance: powder
- Application: intermediate
- DeliveryTime: IN STOCK
- PackAge: according to your needs
- Port: Shang Hai
- ProductionCapacity: 1 Metric Ton/Day
- Purity: 99%
- Transportation: Courier,Air,Sea
- LimitNum: 1 Milligram
Superiority
Rimegepant sulfate Basic information
Product Name: Rimegepant sulfate
Synonyms: [(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl]4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate;(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate hemisulfate sesquihydrate;RIMEGEPANT SULFATE;Rimegepant sulfate hydrate【Chemical name：1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester, sulfate, hydrate (2:1:3)】;(5S,6S,9R)-5-amino-6-(2,3difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b] pyridin-9-yl4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylate hemisulfate sesquihydrate;Rimegepant sulfate hydrate
CAS: 1374024-48-2
MF: C28H30F2N6O7S
MW: 632.64
EINECS: 822-372-0
Product Categories: API
Mol File: 1374024-48-2.mol
Details
Rimegepant sulfate Usage And Synthesis
Description Rimegepant sulfate is a small molecule, highly selective calcitonin gene-related peptide antagonist (CGRP) developed by Biohaven Pharmaceutical Holdings, Inc. and approved by the FDA for the acute treatment of migraine. rimegepant and ubrogepant are the only CGRP antagonists with oral bioavailability. Because of the absence of vasoconstrictive properties observed with oral CGRP antagonists, the use of rimegepant is safer and more reliable in patients with contraindications to standard therapy[1].
Side effects Common side effects of Rimegepant sulfate are nausea, which may be severe enough to cause shortness of breath, difficulty breathing; swelling of the face, eyes, mouth, throat, tongue, or lips; rash, measles; and itching.
Synthesis Rimegepant sulfate is prepared by the reaction of rimegepant and water.
Step: With sulfuric acid In ethanol at 20 - 70℃; Solvent; Temperature.
Rimegepant sulfate synthesis
References [1] J S. Rimegepant: First Approval.[J]. Drugs, 2020, 80 7: 741-746. DOI:10.1007/s40265-020-01301-3.