L-SEPIAPTERIN , CAS 17094-01-8 ,98%+ CAS NO.17094-01-8

L-SEPIAPTERIN Basic information
Product Name:    L-SEPIAPTERIN
Synonyms:    (S)-2-aMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(1H)-one;(S)-2-AMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(3H)-one;Sepiapterin solid;S(-)-2-AMINO-7,8-DIHYDRO-6-(2-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE;SEPIAPTERIN;L-SEPIAPTERIN;L-SEPIAPTERIN DIHYDRATE;2-AMINO-7,8-DIHYDRO-6-(2S-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE
CAS:    17094-01-8
MF:    C9H11N5O3
MW:    237.22
EINECS:    
Product Categories:    
Mol File:    17094-01-8.mol

L-SEPIAPTERIN Chemical Properties
Melting point     >270 °C (dec.)
Boiling point     448.1±55.0 °C(Predicted)
density     1.86±0.1 g/cm3(Predicted)
storage temp.     -20°C
solubility     DMSO: 27 mg/mL
pka    12.33±0.20(Predicted)
form     solid
color     yellow
Stability:    Light Sensitive
CAS DataBase Reference    17094-01-8
Safety Information
Safety Statements     24/25
WGK Germany     3
MSDS Information
Provider    Language
ACROS    English
SigmaAldrich    English
L-SEPIAPTERIN Usage And Synthesis
Chemical Properties    yellow to orange powder
Uses    L-Sepiapterin serves as a substrate for BH4 synthesis via the pterin salvage pathway. It inhibits rat liver GTP cyclohydrolase with an IC50 value of approximately 25 μM. It can be used to circumvent the inhibition of pterin biosynthesis by 2,4-diamino-6-hydroxy pyrimidine.[Cayman Chemical]
Uses    Sepiapterin improved the endothelial dysfunction in SMA from db?/db mice by decreasing oxidative stress. Sepiapterin is commonly used in the study for treamtment of Type I Diabetes
Uses    Sepiapterin can be used to induce sequence-specific photolesions in double-stranded DNA.
Definition    ChEBI: L-sepiapterin is a sepiapterin with L configuration.
General Description    Sepiapterin, a pteridine derivative, is a stable precursor of tetrahydrobiopterin (BH4). It is a yellow pigment found in sepia mutant of Drosophila melanogaster and lemon Bombyx mori mutant (silkworm).
Biochem/physiol Actions    Cofactor of nitric oxide synthase; intracellularly converted to tetrahydro-biopterin leading to the stimulation of nitric oxide.
L-SEPIAPTERIN Preparation Products And Raw materials