Mycophenolic acid 24280-93-1 CAS NO.24280-93-1

4-methyl-5-methoxy-7-hydroxy-6-(5-carboxy-3-methylpent-2-en-1-yl)-phthalide;6-(5-carboxy-3-methyl-2-pentenyl)-7-hydroxy-5-methoxy-4-methyl-phthalid;lilly-68618;melbex;micofenolicoacido;nsc-129185;(4E)-6-(1,3-DIHYDRO-4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-ISOBENZOFURANYL)-4-METHYL-4-HEXENOIC ACID;6-(4-HYDROXY-6-METHOXY-7-METHYL-3-OXO-5-PHTHALANYL)-4-METHYL-4-HEXANOIC ACID

Mycophenolic acid Chemical Properties

mp  141°C
storage temp.  2-8°C

solubility  methanol: 50 mg/mL, clear, colorless to faintly yellow

form  powder

Merck  13,6352
CAS DataBase Reference 24280-93-1(CAS DataBase Reference)

Safety Information

Hazard Codes  Xn
Risk Statements  22-61-40
Safety Statements  53-45-36/37
RIDADR  2811
WGK Germany  3

RTECS  MP8050000

F  10
HazardClass  6.1(b)
PackingGroup  III

Mycophenolic acid Usage And Synthesis

Chemical Properties White to Off-White Powder
Usage An antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.
Usage immune suppressant, antineoplastic, antiviral
Usage antineoplastic, progestin
Usage Mycophenolic acid is a common Penicillium metabolite first reported in the 1930s as a possible mycotoxin. Re-investigation showed mycophenolic acid to display broad antitumour, antiviral, antifungal and antiprotozoan activities. Its potent immunosuppressant activity led to its commercial development to prevent kidney transplant rejection. Mycophenolic acid acts by inhibiting inosine monophosphate dehydrogenase, controlling the rate of de novo purine synthesis in proliferating B and T lymphocytes.
Biological Activity Immunosuppressive agent with antiviral and antitumor effects in vitro and in vivo . Potently inhibits inosine monophosphate dehydrogenase, thus inhibiting de novo GTP synthesis leading to decreased RNA and DNA synthesis. Reversibly inhibits proliferation of T and B lymphocytes and antibody formation.