China (Mainland)
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SB 431542 CAS NO.301836-41-9
- Min.Order: 1 Gram
- Payment Terms: T/T,MoneyGram,Other
- Product Details
Keywords
- SB 431542
- 301836-41-9
- 98% purity
Quick Details
- ProName: SB 431542
- CasNo: 301836-41-9
- Molecular Formula: C22H16N4O3
- Appearance: powder
- Application: intermediate
- DeliveryTime: in stock
- PackAge: accroding to the need
- Port: Shanghai Port
- ProductionCapacity: 100 Kilogram/Day
- Purity: 98% purity
- Storage: Sealed in dry,Room Temperature
- Transportation: air，sea and courier
- LimitNum: 1 Gram
- Grade: Industrial Grade,Pharma Grade,Electron...
Superiority
Product Name: SB 431542
Synonyms: SB-431542/SB431542;SB 431542, >=98%;4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide SB431542;SB 431542 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide;4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate;SB 431542;4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE;4-[4-(3,4-METHYLENEDIOXYPHENYL)-5-(2-PYRIDYL)-1H-IMIDAZOL-2-YL]-BENZAMIDE
CAS: 301836-41-9
MF: C22H16N4O3
MW: 384.39
EINECS:
Mol File: 301836-41-9.mol
Details
Melting point 214 °C(dec.)
Boiling point 662.4±55.0 °C(Predicted)
density 1.373
Fp 354.4℃
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO: 10 mg/mL, soluble
pka 10.14±0.10(Predicted)
form powder
InChIKey FHYUGAJXYORMHI-UHFFFAOYSA-N
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 29349990
MSDS Information
SB 431542 Usage And Synthesis
Uses SB 431542 is a known Src family kinase inhibitor that effectively blocks the transforming growth factor-β1-induced cell migration and invasion in both established and primary carcinoma cells.
Definition ChEBI: A member of the class of benzamides that is 4-(imidazol-2-yl)benzamide carrying additional 1,3-benzodioxol-5-yl and pyridin-2-yl substituents at positions 4 and 5 respectively on the imidazole ring.
Biological Activity Potent and selective inhibitor of the transforming growth factor- β (TGF- β ) type I receptor activin receptor-like kinase ALK5 (IC 50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF- β -induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells.