Estriol 50-27-1 USP38 top in the market CAS NO.50-27-1

roduct Name: Estriol
Synonyms: TRIDESTRIN;(16-alpha,17-beta)-estra-1,3,5(10)-triene-3,16,17-triol;(16alpha,17beta)-Estra-1,3,5(10)-triene-3,16,17-triol;(16-alpha,17-beta)-oestra-1,3,5(10)-triene-3,16,17-triol;(16alpha,17beta)-Oestra-1,3,5(10)-triene-3,16,17-triol;1,3,5-estratriene-3-beta,16-alpha,17-beta-triol;1,3,5-Estratriene-3beta,16-alpha,17-beta-triol;1,3,5-oestratriene-3-beta,16-alpha,17-beta-triol
CAS: 50-27-1
MF: C18H24O3
MW: 288.38
EINECS: 200-022-2
Product Categories: Steroids;Hormone;Biochemistry;Hydroxysteroids;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroid and Hormone;API;THEELOL;Hormone Drugs;Inhibitors
Mol File: 50-27-1.mol
Estriol Structure
Estriol Chemical Properties
Melting point  280-282 °C(lit.)
refractive index  58 ° (C=0.4, Dioxane)
storage temp.  -20°C Freezer
Merck  3707
CAS DataBase Reference 50-27-1(CAS DataBase Reference)
NIST Chemistry Reference Estriol(50-27-1)
Safety Information
Hazard Codes  T,F
Risk Statements  60-61-40-45-39/23/24/25-23/24/25-11
Safety Statements  53-22-36/37/39-45-36/37-16
WGK Germany  3
RTECS  KG8225000
F  8-10
Hazardous Substances Data 50-27-1(Hazardous Substances Data)

Purpose and Function 1. It can be used for treating cervicitis and especially suitable for treating menopausal syndrome and senile vaginitis.
2. It can also be used as the adjuvant drug for middle-term labor induction and artificial abortion. 3. It can also be used for treating prostatic hypertrophy and prostate cancer.
4. It still has a rapid role in increasing the peripheral leukocytes. It generally takes effect at 1 to 3 days after the treatment but with a short duration period. It also has efficacy in treating leukopenia caused by chemotherapy or radiotherapy.
5. It can be used for reducing the vascular permeability and fragility and can be used for the treatment of various kinds of hemorrhage. It also has quick hemostasis effect on menorrhagia, hysterectomy or tonsillectomy.
Precautions 1. Pregnant and lactating women, patients of breast hyperplasia, breast lumps, gynecological cancer, and aplastic anemia patients should be disabled with minor patients being not suitable for using it.
2. Patients of heart (liver, kidney) disease, hypertension, diabetes, epilepsy, migraine (including medical history), endometriosis, fibrocystic breasts, porphyria, hyperlipidemia or having history of pregnancy itching and herpes should take with caution.
3. If prescribed therapy doesn’t work, it is not suitable for increasing the dose or extending the usage time.
Drug Interactions It can be used in combination with estradiol with competitive antagonism.
Storage It should be sealed upon shading for storage.
Chemical Properties It is white crystalline powder with the M.p. being 283 ℃, relative density being 1.27, and the specific rotation being [α] 25D + 34.4°(pyridine) and 25D + 58°± 5°(4%, dioxane). Its ethanol solution has maximum absorption at the wavelength of 280 nm. The crystal is insoluble in water, slightly soluble in ethanol (1: 500), diethyl ether, chloroform, dioxane and vegetable oil and easily soluble in pyridine and alkali hydroxide solution.
Uses It belongs to estrogen drug. It can be used for treating leukopenia, various kinds of menopathy, senile vaginitis, and menopausal syndrome. You may also get temporary breast swelling and lumps, menstrual cycle disorders with self-recovery after stopping the drug for about 1 month. Patients of breast hyperplasia, breast lumps, and cancer potentially being related to female hormone-related cancer, aplastic anemia and liver disease patients should be disabled.
Production method Take estrone as raw material; go through acetylation, epoxidation, and reduction to obtain the estriol products.
Estrone [acetylation] → [16, 17- epoxidation] → [rearrangement] → [Restore] → [hydrolysis] → finished product of estriol.
Estrone acetate successively goes through followed enolization, acetylation, epoxidation and reduction to obtain it.
Chemical Properties White Crystalline Powder
Usage 17b-estradiol metabolite, primary estrogen in urine
Usage A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol.