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Home > Products >  Tropinone

Tropinone CAS NO.532-24-1

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  • Min.Order: 100 Kilogram
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  • Product Details

Keywords

  • Tropinone
  • 532-24-1
  • 98%

Quick Details

  • ProName: Tropinone
  • CasNo: 532-24-1
  • Molecular Formula: C8H13NO
  • Appearance: crystalline
  • Application: intermediate
  • DeliveryTime: in stock
  • PackAge: aluminum foil bag
  • Port: Shanghai
  • ProductionCapacity: 20 Kilogram/Quarter
  • Purity: 98%
  • Storage: 2-8°C
  • Transportation: sea,air,courier
  • LimitNum: 100 Kilogram

Superiority

Melting point     40-44 °C(lit.)
Boiling point     113 °C25 mm Hg(lit.)
density     1.0268 (rough estimate)
refractive index     1.4598 (estimate)
Fp     194 °F
storage temp.     2-8°C
pka    8.93±0.20(Predicted)
form     crystalline
color     brown
PH    8 (18g/l, H2O, 20℃)
BRN     2329
InChIKey    QQXLDOJGLXJCSE-KNVOCYPGSA-N
CAS DataBase Reference    532-24-1(CAS DataBase Reference)
NIST Chemistry Reference    8-Azabicyclo[3.2.1]octan-3-one, 8-methyl-(532-24-1)
EPA Substance Registry System    8-Azabicyclo[3.2.1]octan-3-one, 8-methyl- (532-24-1)

Details

Tropinone Usage And Synthesis
Chemical Properties    Tropinone is a white to light yellow crystal powder, It is an alkaloid and a precursor to a number of additional plant alkaloids. Tropinone is the first intermediate in the biosynthesis of the pharmacologically important tropane alkaloids that possesses the 8-azabicyclo[3.2.1]octane core bicyclic structure that defines this alkaloid class. Chemical synthesis of tropinone was achieved in 1901 but the mechanism of tropinone biosynthesis has remained elusive.
Uses    Tropinone is an oxidative product of Tropane, used to synthesize Morphine and Tropane alkaloids.
Preparation    The first synthesis of tropinone was by Richard Willstätter in 1901. It started from the seemingly related cycloheptanone, but required many steps and had an overall yield of only 0.75%.Willstätter had previously synthesized cocaine from tropinone, in what was the first synthesis and elucidation of the structure of cocaine.
The 1917 synthesis by Robinson is considered a legend in total synthesis due to its simplicity and biomimetic approach. Tropinone is a bicyclic molecule, but the reactants used in its preparation are fairly simple: succinaldehyde, methyl amine and acetone dicarboxylic acid (or even acetone). The synthesis is a good example of a biomimetic reaction or biogenetic-type synthesis because biosynthesis makes use of the same building blocks. It also demonstrates a tandem reaction in a one-pot synthesis. Furthermore the yield of the synthesis was 17% and with subsequent improvements exceeded 90%. 

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