Pyrimethamine CAS NO.58-14-0

Pyrimethamine Chemical Properties
Melting point     233-234°C
Boiling point     393.35°C (rough estimate)
density     1.2171 (rough estimate)
refractive index     1.6110 (estimate)
storage temp.     0-6°C
solubility     Prepare the solution immediately before use. Dissolve 0.25 g in a mixture of 1 volume of methanol R and 3 volumes of methylene chloride R and dilute to 10 mL with the same mixture of solvents. The solution is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).
pka    pKa 7(t=20.0) (Uncertain)
form     neat
Water Solubility     <0.01 g/100 mL at 21 ºC
λmax    276nm(lit.)
Merck     14,7985
BRN     219864
Stability:    Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference    58-14-0(CAS DataBase Reference)
NIST Chemistry Reference    Pyrimethamine(58-14-0)
IARC    3 (Vol. 13, Sup 7) 1987
EPA Substance Registry System    Pyrimethamine (58-14-0)        

Pyrimethamine Basic information
Pharmacology and mechanism of action Preparations Antiprotozoal veterinary drug Role and purpose Pharmacokinetics Side effects Precautions Medicine interactions Dosage References
Product Name:    Pyrimethamine
Synonyms:    2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;[2-amino-5-(4-chlorophenyl)-6-ethyl-pyrimidin-4-yl]amine;Pyrimethamine,5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;Pyrimethamine (200 mg);PyriMethaMine,darapriM;5-(p-chlorophenyl)-6-ethyl-4-pyrimidinediamine;BW 50-63;bw50-63
CAS:    58-14-0
MF:    C12H13ClN4
MW:    248.71
EINECS:    200-364-2
Mol File:    58-14-0.mol

Safety Information
Hazard Codes     Xn
Risk Statements     22-36
Safety Statements     26
RIDADR     3249
WGK Germany     3
RTECS     UV8140000
HazardClass     6.1(b)
PackingGroup     III
HS Code     29335990
Toxicity    LD50 oral in rat: 440mg/kg