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Home > Products >  Miltefosine

Miltefosine CAS NO.58066-85-6

  • Min.Order: 1 Gram
  • Payment Terms: T/T,MoneyGram,Other
  • Product Details

Keywords

  • 58066-85-6
  • Miltefosine
  • 99% purity

Quick Details

  • ProName: Miltefosine
  • CasNo: 58066-85-6
  • Molecular Formula: C21H46NO4P
  • Appearance: Crystalline Powder
  • Application: intermediate
  • DeliveryTime: in stock
  • PackAge: According to the need of packing
  • Port: Shanghai
  • ProductionCapacity: 100 Kilogram/Month
  • Purity: 99% purity
  • Storage: room temp
  • Transportation: air,sea,courier
  • LimitNum: 1 Gram

Superiority

Product Name:    Miltefosine
Synonyms:    2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-n,n,n-trimethyl-ethanaminiuhydrox;2-(((hexadecyloxy)hydroxyphosphinyl)oxy)-n,n,n-trimethylethanaminiumhydroxid;cholinephosphate,hexadecylester,hydroxide,innersalt;d18506;Hexadecyl 2-(trimethylamino)ethyl phosphate;Miltex;13-18506;2-[[(Hexadecyloxy)hydroxyphasphinyl]oxy]-N,N,N-trimethylethanaminiminner salt
CAS:    58066-85-6
MF:    C21H46NO4P
MW:    407.57
EINECS:    622-572-6
Product Categories:    Inhibitors;Anti-cancer&immunity;Anti-virals;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;Miscellaneous Natural Products;MILTEX;inhibitor
Mol File:    58066-85-6.mol

Details

Melting point     232-234° (dec)
storage temp.     room temp
solubility     H2O: soluble10mg/mL, clear, colorless
form     Crystalline solid
InChIKey    PQLXHQMOHUQAKB-UHFFFAOYSA-N
CAS DataBase Reference    58066-85-6(CAS DataBase Reference)
Safety Information
Hazard Codes     Xn
Risk Statements     22-43
Safety Statements     36/37
RIDADR     UN 2811 6.1 / PGIII
WGK Germany     3
RTECS     KH2890000
Toxicity    LD50 in rats (mg/kg): 246 orally (Muschiol)


Description    Miltefosin, representing the prototype of a new phospholipid structure, was introduced for the palliative treatment of skin metastases in patients with breast cancer. It is highly active against the human leukemia tumor cells xenograft in nude mice, leading to growth inhibition and regression of large established tumors. Its mode of antitumor activity is not mediated by the host immune system but by its pharmacological effects at the level of the cancer cell membrane, distinctly different from that of the classical cytostatic drugs which interact with cell proliferation at the level of DNA replication. Protein kinase C inhibition has been suggested as a possible mechanism.

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