Methotrexate CAS NO.59-05-2

Methotrexate Chemical Properties
Melting point     195°C
alpha     +17～+24°(D/20℃)(c=1,Na2CO3 soln.)(calculated on the dehydrous basis)
Boiling point     561.26°C (rough estimate)
density     1.4080 (rough estimate)
refractive index     1.6910 (estimate)
Fp     11℃
storage temp.     Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility     H2O: insoluble
form     powder
pka    pKa 3.04/4.99(H2O,t =25,I=0.0025) (Uncertain)
Water Solubility     Insoluble. <0.1 g/100 mL at 19 ºC
Sensitive     Light Sensitive & Hygroscopic
Merck     14,5985
BRN     70669
Stability:    Stable, but light sensitive and hygroscopic. Incompatible with strong acids, strong oxidizing agents. Store at -15C or below.
InChIKey    FBOZXECLQNJBKD-ZDUSSCGKSA-N
CAS DataBase Reference    59-05-2(CAS DataBase Reference)
IARC    3 (Vol. 26, Sup 7) 1987
NIST Chemistry Reference    Methotrexate(59-05-2)
EPA Substance Registry System    Methotrexate (59-05-2)                          

Methotrexate Basic information
Treatment of cancer and rheumatoid arthritis History of discovery Immunosuppressants Pharmacological effects Pharmacokinetics Clinical application Dosage Adverse reactions and precautions Drug Interactions Chemical Properties Production method
Product Name:    Methotrexate
Synonyms:    METHOTREXATEFORINJECTION;sodium 4-[[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]am ino]-5-hydroxy-5-oxo-pentanoate;METHOTREXATE(N-(4-(((2,4-DIAMINO-6-PTERIDINYL)METHYLAMINO)BENZOYL)-L-GLUTAMICACID);4-Amino-N10-methylfolic acid;Glutamic acid, N-[p-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(+)- (8CI);L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI);L-Methotrexate;Methotrexat-Ebewe
CAS:    59-05-2
MF:    C20H22N8O5
MW:    454.45
EINECS:    200-413-8
Mol File:    59-05-2.mol

Safety Information
Hazard Codes     T,F
Risk Statements     61-25-36/38-46-39/23/24/25-23/24/25-11
Safety Statements     53-26-36/37-45-36/37/39-36-16
RIDADR     UN 2811 6.1/PG 3
WGK Germany     3
RTECS     MA1225000
F     3-8-10
TSCA     Yes
HazardClass     6.1(b)
PackingGroup     III
HS Code     29335995
Hazardous Substances Data    59-05-2(Hazardous Substances Data)
Toxicity    LD50 oral in rat: 135mg/kg