China (Mainland)
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Larazotide CAS NO.881851-50-9
- Min.Order: 1 Metric Ton
- Payment Terms: T/T
- Product Details
Keywords
- Larazotide
- 881851-50-9
- 98%
Quick Details
- ProName: Larazotide
- CasNo: 881851-50-9
- Molecular Formula: C34H59N9O12
- Appearance: color
- Application:
- DeliveryTime: In Stock
- PackAge: According to your needs
- Port: ShangHai
- ProductionCapacity: 1000 Metric Ton/Day
- Purity: 98%
- Storage: storage temp
- Transportation: by Sea，AIR，Courier
- LimitNum: 1 Metric Ton
Superiority
生物活性Larazotideacetate是一种合成肽，是一种紧密连接(junction)的调节剂。靶点Paracellularpermeability体外研究Larazotideacetateinhibitstheredistributionandrearrangementofzonulaoccludens-1(ZO-1)andactincausedbyAT-1002andgliadinfragmentsinCaco-2andIEC6cells.LarazotideacetateinhibitstheAT-1002-inducedTEERreductionandTJopeninginCaco-2cells.Larazotideacetateinhibitsthetranslocationofagliadin13-merpeptidChemicalbooke,whichhasbeenimplicatedinceliacdisease,acrossCaco-2cellmonolayers.Further,apicallyappliedLarazotideacetateinhibitstheincreaseinTJpermeabilityelicitedbybasolaterallyappliedcytokines.体内研究Whentestedinvivoingliadin-sensitizedHLA-HCD4/DQ8doubletransgenicmice,larazotideacetateinhibitsgliadin-inducedmacrophageaccumulationintheintestineandpreservednormaltightjunctionstructure.
Details
Larazotide
H-GLY-GLY-VAL-LEU-VAL-GLN-PRO-GLY-OH;Larazotideacetate;LARAZOTIDEACETATE(>90%);inhibiChemicalbookt,Larazotideacetate,Larazotide,Inhibitor,GapJunctionProtein
881851-50-9
C34H59N9O12
785.88536
生物活性Larazotideacetate是一种合成肽，是一种紧密连接(junction)的调节剂。靶点Paracellularpermeability体外研究Larazotideacetateinhibitstheredistributionandrearrangementofzonulaoccludens-1(ZO-1)andactincausedbyAT-1002andgliadinfragmentsinCaco-2andIEC6cells.LarazotideacetateinhibitstheAT-1002-inducedTEERreductionandTJopeninginCaco-2cells.Larazotideacetateinhibitsthetranslocationofagliadin13-merpeptidChemicalbooke,whichhasbeenimplicatedinceliacdisease,acrossCaco-2cellmonolayers.Further,apicallyappliedLarazotideacetateinhibitstheincreaseinTJpermeabilityelicitedbybasolaterallyappliedcytokines.体内研究Whentestedinvivoingliadin-sensitizedHLA-HCD4/DQ8doubletransgenicmice,larazotideacetateinhibitsgliadin-inducedmacrophageaccumulationintheintestineandpreservednormaltightjunctionstructure.