China (Mainland)
Assessedsupplier
iRGD CAS NO.1392278-76-0
- Min.Order: 1 Metric Ton
- Payment Terms: T/T
- Product Details
Keywords
- iRGD
- 1392278-76-0
- 98%
Quick Details
- ProName: iRGD
- CasNo: 1392278-76-0
- Molecular Formula: C35H57N13O14S2
- Appearance: color
- Application:
- DeliveryTime: In Stock
- PackAge: According to your needs
- Port: ShangHai
- ProductionCapacity: 1000 Metric Ton/Day
- Purity: 98%
- Storage: storage temp
- Transportation: by Sea，Air and Courier
- LimitNum: 1 Metric Ton
Superiority
iRGDpeptide-mediatedtumorpenetrationoccursinthreesteps:bindingtoαv-integrinsontumorvasculatureortumorcells,exposurebyproteolysisofaC-terminalmotifthatbindstoneuropilin-1(NRP-1)andcellinternalization.iRGDpeptideinsertedintheICOVIR15KfiberCterminusenhancesbindingandinternalizationonlyinMCF7cells,whichexpressNRP-1andintegrins.iRGDinsertiondoesnotimpairvirusinfectionandreplication.iRGDpeptidealonehasnoobviouseffeChemicalbookctongastriccancercells,andwhencombinedwith5-FU,iRGDpeptide(0.3μmol/mL)enhancesthechemotherapyefficacyof5-FUongastriccancercellsthroughNRP1.体内研究iRGDinsertedintheoncolyticadenovirusICOVIR15K(ICOVIR15K-iRGD)enhancesearlyadenovirusdisseminationthroughthetumormassandelevatestheantitumoreffectinmice.iRGD(4mmol/kg,i.v.)incombinationwith5-FUsignificantlysuppressesthetumorgrowthinnudemicebearinghumangastriccancercells.
Details
iRGDpeptide-mediatedtumorpenetrationoccursinthreesteps:bindingtoαv-integrinsontumorvasculatureortumorcells,exposurebyproteolysisofaC-terminalmotifthatbindstoneuropilin-1(NRP-1)andcellinternalization.iRGDpeptideinsertedintheICOVIR15KfiberCterminusenhancesbindingandinternalizationonlyinMCF7cells,whichexpressNRP-1andintegrins.iRGDinsertiondoesnotimpairvirusinfectionandreplication.iRGDpeptidealonehasnoobviouseffeChemicalbookctongastriccancercells,andwhencombinedwith5-FU,iRGDpeptide(0.3μmol/mL)enhancesthechemotherapyefficacyof5-FUongastriccancercellsthroughNRP1.体内研究iRGDinsertedintheoncolyticadenovirusICOVIR15K(ICOVIR15K-iRGD)enhancesearlyadenovirusdisseminationthroughthetumormassandelevatestheantitumoreffectinmice.iRGD(4mmol/kg,i.v.)incombinationwith5-FUsignificantlysuppressesthetumorgrowthinnudemicebearinghumangastriccancercells.