Guanidine hydrochloride 50-01-1 Large in supply CAS NO.50-01-1

Synonyms: guanidine,monohydrochloride;guanidinechloride;Guanidinemonohydrochloride;guanidiniumhydrochloride;usafek-749;CARBAMIDINE HYDROCHLORIDE;IMINOUREA HYDROCHLORIDE;GUANIDINIUM CHLORIDE
CAS: 50-01-1
MF: CH6ClN3
MW: 95.53
EINECS: 200-002-3
Product Categories: Pharmaceutical Intermediates;Miscellaneous Biochemicals;proteinmod;Inhibitors
Mol File: 50-01-1.mol
Guanidine hydrochloride Structure
Guanidine hydrochloride Chemical Properties
Melting point  180-185 °C(lit.)
density  1.18 g/mL at 25 °C(lit.)
refractive index  n20/D 1.465
storage temp.  Store at RT.
solubility  H2O: 6 M, clear, colorless
PH 4.5-5.5 (100g/l, H2O, 20℃)
Water Solubility  2280 g/L (20 ºC)
Sensitive  Hygroscopic
Merck  14,4562
BRN  3591990
Stability: Stable. Hygroscopic. Incompatible with strong oxidizing agents.
CAS DataBase Reference 50-01-1(CAS DataBase Reference)
EPA Substance Registry System Guanidine, monohydrochloride(50-01-1)
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  22-36/38
Safety Statements  26-36-22
WGK Germany  1
RTECS  MF4300000
F  3-10
TSCA  Yes
HS Code  29252000

Protein Denaturation Guanidine Hydrochloride (GdnHCl) is a better denaturant than urea.It should normally give higher and lower values for m and for Cm, respectively, but identical deltaG° values. Since m values in both denaturants can be predicted/estimated from the size of the protein (Myers et al., 1995) and delatG° should not change, yes it is possible-in principle-to predict Cm in one denaturant, knowing its value in the other.
but to have a general correlation co-efficient is almost impossible as every protein has unique folding. Though such co-relation may be found for a special protein fold, but what purpose it may serve apart from giving a tentative idea that GdnHCl or urea may be a better denaturant! If you are looking for even better denaturant than Gdn HCl then use GdnSCN, it is better and more effective.
Uses Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
Drug intermediates Guanidine hydrochloride drug used primarily as an intermediate in the manufacture of sulfadiazine, an important raw material sulfamethyldiazine, sulfamethazine and folic acid.
Guanidine hydrochloride (or guanidine nitrate) and ethyl cyanoacetate reaction, cyclization of 2,4-diamino-6-hydroxy pyrimidine, folic acid for the synthesis of antianemic. Furthermore guanidine hydrochloride also used synthetic anti-static agent.
Preparation In Dicyanodiamide and ammonium (Ammonium chloride) as raw material, melt reaction at 170-230 ℃, guanidine hydrochloride obtained crude, refined products.

hemical properties White or yellowish lumps; Solubility in 20 °C: 200g/100g in water; 76g/100g in methanol; 24g/ 100g in ethanol; Almost insoluble in acetone, benzene and ether.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Uses 1. For organic synthesis and pharmaceutical industry.
2. Mainly used as a pharmaceutical intermediate; an important raw material for producing sulfadiazine, sulfamethyldiazine, sulfamethazine and folic acid.
3. Used as intermediates for synthesis of medicine, pesticides, dyes and other organics. For synthesis of 2-amino-pyrimidine, 2-amino-6-methyl-pyrimidine, and 2-amino-4,6-dimethyl-pyrimidine. A intermediate for producing sulfadiazine, sulfamethyldiazine, and sulfamethazine. Guanidine hydrochloride (or guanidine nitrate) can be reacted with ethyl cyanide for cyclization into 2,4-diamino-6-hydroxy-pyrimidine. This is for synthesis of anti-anemia drugs: folic acid. It can also be used for the synthesis of anti-static agent of synthetic fiber.

Chemical Properties White cryst. powder
Uses cholinergic
Uses Guanidine has a good bacterial and fungicidal efficacy when used in low concentration and can also be used as disinfectant.
Uses Used to synthesis medicine, pesticide, dye and other organic compound, is the important material to make sulfanilamide medicine and folacin, and can be used as anti-static agent of compound fibre.
Definition ChEBI: An aminocarboxamidine, the parent compound of the guanidines.