Bromhexine hydrochloride. CAS NO.611-75-6

Bromhexine hydrochloride Basic information
Product Name:    Bromhexine hydrochloride
Synonyms:    2-AMINO-3,5-DIBROMO-N-CYCLOHEXYL-N-METHYLBENZY-LAMINE HYDROCHLORIDE;n-(2-amino-3,5-dibromobenzyl)-n-methylcyclohexylamine hydrochloride;2-amino-3,5-dibromo-n-cyclohexyl-n-methyl-benzenemethanaminmonohydrochlo;2-amino-n-cyclohexyl-3,5-dibromo-n-methylbenzylaminehydrochloride;2-amino-n-cyclohexyl-3,5-dibromo-n-methyl-benzylaminhydrochloride;bisolvon;bisolvonhydrochloride;bromessina
CAS:    611-75-6
MF:    C14H21Br2ClN2
MW:    412.59
EINECS:    210-280-8
Product Categories:    ROCEPHIN;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;611-75-6
Mol File:    611-75-6.mol

Bromhexine hydrochloride Chemical Properties
Melting point     240-244 °C
storage temp.     Sealed in dry,Room Temperature
solubility     Very slightly soluble in water, slightly soluble in alcohol and in methylene chloride.
form     powder
color     White to Light Beige
λmax    307nm(Decane)(lit.)
Merck     14,1391
BRN     4848376
InChIKey    UCDKONUHZNTQPY-UHFFFAOYSA-N
LogP    5.081 (est)
CAS DataBase Reference    611-75-6(CAS DataBase Reference)
Safety Information
Hazard Codes     Xn
Risk Statements     20/21/22-36/37/38
Safety Statements     22-24/25-36-26
WGK Germany     2
RTECS     XS9950000
HS Code     29215990

Description    Bromhexine Hydrochloride is the hydrochloride salt form of bromhexine, a secretolytic, with mucolytic activity. Upon administration, bromhexine increases lysosomal activity and enhances hydrolysis of acid mucopolysaccharide polymers in the respiratory tract. This increases the production of serous mucus in the respiratory tract, which makes the phlegm thinner and decreases mucus viscosity. This contributes to its secretomotoric effect, and allows the cilia to more easily transport the phlegm out of the lungs. This clears mucus from the respiratory tract and may aid in the treatment of respiratory disorders associated with abnormal viscid mucus, excessive mucus secretion and impaired mucus transport.
Chemical Properties    White Solid
Uses    Bromhexine hydrochloride was used in the secretion of pancreatic juice of low viscosity.
Uses    Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
Bromhexine hydrochloride belongs to the group of expectorants (mucoactive agents). The active substance has a secretolytic effect. It is used for the treatment of strong cough, e.g. triggered by a bronchitis.