Indobufen CAS NO.63610-08-2

Product Name:    Indobufen
Synonyms:    1-Oxo-2-[p-[(α-ethyl)carboxyMethyl]phenyl]isoindoline;2-[p-(1-Oxo-2-isoindolinyl)phenyl]butyric Acid;K 2930;(+-)-butyricaci;1-oxo-2-(p-((alpha-ethyl)carboxymethyl)phenyl)isoindoline;4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-ethyl-benzeneaceticacid;2-[4-(1-OXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PHENYL]-BUTYRIC ACID;lndobufen
CAS:    63610-08-2
MF:    C18H17NO3
MW:    295.34
EINECS:    264-364-4
Product Categories:    Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:    63610-08-2.mol

Melting point     182-184°
Boiling point     518.1±50.0 °C(Predicted)
density     1.275±0.06 g/cm3(Predicted)
storage temp.     Keep in dark place,Sealed in dry,Room Temperature
pka    4.39±0.10(Predicted)
CAS DataBase Reference    63610-08-2(CAS DataBase Reference)
EPA Substance Registry System    Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-.alpha.-ethyl- (63610-08-2)

Description    Indobufen is a platelet aggregation inhibitor related to the antiinflammatory agent indoprofen. It has shown clinical efficacy in peripheral artery disease, in prevention of deep vein thrombosis after myocardial infarction, and in blocking excercise-induced increase in platelet aggregation in angina patients.
Originator    Erbamont (Italy)
Uses    Indobufen is a platelet aggregation inhibitor. Indobufen is the anticoagulant drug and platelet aggregation inhibitor, which has anti-inflammatory analgesic effect. Indobufen is used as an antithrombotic.
Brand name    IBUSTRIN
Clinical Use    A reversible but very potent inhibitor of platelet COX-1 activity, was shown to have comparable clinical efficacy to that of aspirin in prevention of DVT after myocardial infarction and in blocking exercise-induced increase in platelet aggregation. In the secondary prevention of thromboembolic events, 100 or 200 mg of indobufen twice daily is as effective as warfarin or aspirin in patients with or without atrial fibrillation. Currently, indobufen is only available for routine clinical use in Europe.