Tripeptide-1 CAS NO.72957-37-0

Tripeptide-1 Basic information
Product Name:    Tripeptide-1
Synonyms:    H-GLY-HIS-LYS-OH ACETATE SALT;H-GLY-HIS-LYS-OH ACOH;GLY-HIS-LYS ACETATE;GLY-HIS-LYS ACETATE SALT;GLY-HIS-LYS ACOH H2O;GLYCYL-L-HISTIDYL-L-LYSINE ACETATE;LIVER CELL GROWTH FACTOR;LIVER CELL GROWTH FACTOR ACETATE SALT
CAS:    72957-37-0
MF:    C16H28N6O6
MW:    400.44
EINECS:    277-125-4
Product Categories:    Amino Acid Derivatives;72957-37-0
Mol File:    72957-37-0.mol

Tripeptide-1 Chemical Properties
storage temp.     -20°C
form     powder
color     white
Sequence    Gly-His-Lys
InChIKey    MGNUTAFMLGJBGV-ACMTZBLWSA-N
SMILES    C(=O)(O)C.[C@@H](NC(=O)CN)(C(=O)N[C@H](C(=O)O)CCCCN)CC1N=CNC=1 |&1:4,13,r|
CAS DataBase Reference    72957-37-0(CAS DataBase Reference)

Tripeptide-1 Usage And Synthesis
Description    Tripeptide-1 is a small peptide composed of three amino acids  (glycine-histidine-lysine or GHK) and is known for type I collagen fragments. When collagen fragment peptides (GHK) are added, it may mistakenly lead the skin to think that collagen has been broken down, resulting in more collagen. Therefore, tripeptide-1 is believed to stimulate collagen production in the skin. More collagen will reduce wrinkles on the face, which will improve the condition of the skin.
Chemical Properties    White powder
Uses    Liver Cell Growth Factor
Uses    Gly-His-Lys acetate salt has been used:

    individually or as a complex with copper to test its effect on cytokines production in the human normal fibroblasts cell lines
    as a model peptide in N,N-dimethyl-N-methacryloxyethyl-N-(3-sulfopropyl)ammonium betaine based capillary electrophoresis separation studies
    as a component of Coon′s modified Ham′s F-12 medium for culturing Fischer rat thyroid follicular cell line, FRTL-5

General Description    Gly-His-Lys is a tripeptide present at ～200ng/ml in association with α-globulin and albumin, in human blood plasma.
Biochem/physiol Actions    Gly-His-Lys (GHK) acetate salt displays affinity towards copper(II) ions. This property enables GHK to modulate the copper intake into cells. GHK is also involved in quenching toxic by-products generated by lipid peroxidation.