Cetirizine CAS NO.83881-51-0

Product Name:    Cetirizine
Synonyms:    2-[2-[4-(4-Chlorobenzhydryl)-1-piperazinyl]ethoxy]acetic acid;2-[4-(4-Chlorobenzhydryl)-1-piperazinyl]ethoxyacetic acid;5-[4-[(4-Chlorophenyl)phenylmethyl]piperazino]-3-oxapentanoic acid;Ceterizine;Cetirizine DISCONTINUED (Replaced with C1876);2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)Methyl]piperazin-1-yl}ethoxy)acetic acid;CETIRIZINE LACTOSE ESTER;vidix
CAS:    83881-51-0
MF:    C21H25ClN2O3              
MW:    388.89              
Mol File:    83881-51-0.mol                     

Melting point     110-115°C
Boiling point     542.1±45.0 °C(Predicted)
density     1.237±0.06 g/cm3(Predicted)
storage temp.     Sealed in dry,2-8°C
pka    3.46±0.10(Predicted)
Water Solubility     101 mg/L
CAS DataBase Reference    83881-51-0(CAS DataBase Reference)
EPA Substance Registry System    Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]- (83881-51-0)
Safety Information
WGK Germany     3
RTECS     AG0977500
Hazardous Substances Data    83881-51-0(Hazardous Substances Data)
MSDS Information
Cetirizine Usage And Synthesis
Chemical Properties    white, crystalline powder
Uses    Cetirizine is a metabolite of the first-generation H1 antihistamine hydroxyzine. A reduced dosage (5 mg daily) is recommended in patients with chronic renal or hepatic impairment. Sedative side effects increase with dosages of cetirizine >10 mg per day.
Definition    ChEBI: A member of the class of piperazines that is piperazine in which the hydrogens attached to nitrogen are replaced by a (4-chlorophenyl)(phenyl)methyl and a 2-(carboxymethoxy)ethyl group respectively.
Brand name    Zyrtec (Pfizer).
General Description    Cetirizine, (±)-[2-[4-[(4-chlorophenyl)phenylmethyl]- 1-piperazinyl]ethoxy]acetic acid (Zyrtec), is a racemic compound available as a white crystalline powder that is water soluble. Cetirizine is the primary acid metabolite of hydroxyzine, resulting from complete oxidation of the primary alcohol moiety. This compound is zwitterionic and relatively polar and thus does not penetrate or accumulate in the CNS. Before its introduction in the United States, cetirizine was one of the most widely prescribed H1-antihistamines in Europe. 
Cetirizine is indicated for the temporary relief of runny nose, sneezing, itching of the nose or throat, and/or itchy, watery eyes caused by hay fever or other upper respiratory allergies. It also relieves itching caused by hives (urticaria), but it will not prevent hives or an allergic skin reaction from occurring.
Clinical Use    Cetirizine, the acid metabolite from oxidation of the primary alcohol of the antihistamine hydroxyzine, is a widely used antihistamine. It has a long duration of action and is highly selective for H1 receptors. No cardiotoxicity has been reported, but some drowsiness occurs.
Cetirizine Preparation Products And Raw materials
Raw materials    Ethoxyacetic acid-->Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[2-(2,2-diethoxyethoxy)ethyl]--->Hydroxyzine dihydrochloride-->Cetirizine hydrochloride-->2-[2-[4-[(4-chlorophenyl)phenylmethyl]piperazin-1-yl]ethoxy]ethanol hydrochloride-->4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE-->Carbon-->Sodium chloroacetate-->Chloroacetic acid