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Home > Products >  Ramipril 87333-19-5 EP9.0 large in supply

Ramipril 87333-19-5 EP9.0 large in supply CAS NO.87333-19-5

  • Min.Order: 1 Kilogram
  • Payment Terms: T/T,Other
  • Product Details

Keywords

  • 87333-19-5
  • Ramipril
  • UNIPRIL

Quick Details

  • ProName: Ramipril 87333-19-5 EP9.0 large in su...
  • CasNo: 87333-19-5
  • Molecular Formula: C23H32N2O5
  • Appearance: white powder
  • Application: An antihypertensive. An angiotensin co...
  • DeliveryTime: in stock
  • PackAge: drums
  • Port: Shanghai
  • ProductionCapacity: 20 Metric Ton/Month
  • Purity: EP7.0
  • Storage: dry and cool
  • Transportation: air, courier and sea
  • LimitNum: 1 Kilogram

Superiority

Product Name: Ramipril
Synonyms: PRAMACE;RAMIPRIL;RAMACE;UNIPRIL;TRITACE;(2s-(1(r*(r*)),2-alpha,3a-beta,6a-beta))-henylpropyl)amino)-1-oxopropyl;cyclopenta(b)pyrrole-2-carboxylicacid,octahydro-1-(2-((1-(ethoxycarbonyl)-3-p;[2S,3AS,6AS]-1-[(2S)-2-[[(1S)-1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]AMINO]-1-OXOPROPYL]OCTAHYDROCYCLOPENTA[B]PYRROLE-2-CARBOXYLIC ACID
CAS: 87333-19-5
MF: C23H32N2O5
MW: 416.51
EINECS:
Product Categories: Active Pharmaceutical Ingredients;Ramipril;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Angiotensin;API;Cardiovascular & Blood System Agents
Mol File: 87333-19-5.mol
Ramipril Structure
Ramipril Chemical Properties
Melting point  106-108°C
storage temp.  2-8°C
CAS DataBase Reference 87333-19-5(CAS DataBase Reference)
Safety Information
Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-37/39
RTECS  GY5879600

Details



Description Ramipril (brand name: Altace) is a kind of prodrug which is capable of inhibiting the angiotensin-converting enzyme (ACE) which converting angiotensin I to angiotensin II. It is metabolized to ramiprilat in the liver which exerts the effect of ACE inhibition. It is used for the treatment of hypertension, congestive heart failure and nephropathy. It can also be used for the prevention of heart attack, stroke and cardiovascular death. It can also be used for the treatment of kidney damage due to diabetes with protein-containing urine. Ramiprilat, is the competitive inhibitor of ATI for binding to ACE, further inhibiting the enzymatic proteolysis of ATI to ATII, alleviating the effect of ATII on blood pressure.
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Chemical Properties White Solid
Uses cardiotonic
Uses An inhibitor of the angiotensin- coverting enzyme (ACE)
Uses An antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite
Uses Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]
Ramipril Preparation Products And Raw materials
Raw materials Ethyl acetate-->Dichloromethane-->Acetic acid glacial-->Cyclohexane-->Formamide-->Tetrahydro pyrrole-->L-Alanine-->Methyl propionate-->Cyclopentene-->Palladium carbon fine chemical catalyzer-->Ethyl 3-benzoylacrylate

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