Polymyxin B sulfate 1405-20-5 Large in promotion CAS NO.1405-20-5

Synonyms: POLYMYXIN B;POLYMYXIN-B 2,5-SULFATE;POLYMYXIN B SULFATE;POLYMYXIN B SULFATE, BACILLUS POLYMYXA;POLYMYXIN B SULFATE SALT;POLYMYXIN B SULPHATE;POLYMYXIN B (PMB);POLYMIXIN B SULFATE
CAS: 1405-20-5
MF: C56H100N16O17S
MW: 1301.56
EINECS: 215-774-7
Product Categories: Interferes with Cell Membrane Permeability (Ionophores)Spectrum of Activity;PeptidesCell Signaling and Neuroscience;Protein Kinase InhibitorsMore...Close...;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Kinase/Phosphatase Biology;L - ZAntibiotics;Mechanism of Action;Peptides;beta-Lactam StructureAntibiotics;PeptidesAlphabetic;POLB - POLYMore...Close...;Chemical Structure;P;AntibioticsAntibiotics;Cell Culture;PeptidesMore...Close...;Reagents and Supplements;Intermediates & Fine Chemicals;Pharmaceuticals;AEROSPORIN;antibiotic;Inhibitors;API
Mol File: 1405-20-5.mol
Polymyxin B sulfate Structure
Polymyxin B sulfate Chemical Properties
Melting point  217-220°C (dec.)
storage temp.  2-8°C
solubility  H2O: 50 mg/mL
form  powder
color  colorless or slightly yellow
Water Solubility  Soluble in water at 50mg/ml/n
Merck  13,7656
CAS DataBase Reference 1405-20-5(CAS DataBase Reference)
EPA Substance Registry System Polymyxin B, sulfate(1405-20-5)
Safety Information
Hazard Codes  Xn
Risk Statements  22
Safety Statements  22-24/25
RIDADR  3249
WGK Germany  3
RTECS  TR1150000
F  3-8-10
HazardClass  6.1(b)
PackingGroup  III

Dosage 1. Intravenous injection: Adults and children with normal renal function: 1.5 to 2.5 mg per kilogram of body weight per day (for per kg body weight, generally apply not more than 2.5 mg), divide into 2 times with 1 time every 12 hours of infusion. Dilute every 50mg of the product with 500 mL of 5% glucose solution and further add drop wise. Babies with normal renal function can tolerate a amount of 4 mg/day per kilogram of body weight.
2. Intramuscular injection: Adults and children: apply 2.5 to 3 mg per kilogram of body weight; apply in divided doses with applying 1 time every 4 to 6 hours. For baby, the dosage can be 4 mg per day per kilogram of body weight. For new born children, we can apply to 4.5 mg per time per kilogram of body weight.
3. intrathecal injection (for Pseudomonas aeruginosa meningitis): Each mL of drug solution prepared by the sodium chloride injection contains 5mg. Adults and children with over 2 years of age, apply 5 mg daily; after application of 3 to 4 days, change one time every other day, and continue for at least 2 weeks until the result of cerebrospinal fluid culture becomes negative and the sugar inspection becomes normal. For children less than 2 years of age, apply 2mg 1 time per day for continuous 3 to 4 days (or 2.5mg per every other day); after that, apply 2.5mg every other day, until the test becomes normal.
4. The ophthalmic solution concentration: 1~2.5mg per milliliter.
Drug Interactions We should avoid apply it in combination with drugs causing significant damage to the kidneys, skeletal muscle relaxants, aminoglycoside antibiotics, and anesthetic drugs with significant effect of muscle relaxation (such as enflurane). Also we should avoid simultaneous intravenous administration of quinine, and magnesium. Combining polymyxin B sulfate with sulfa drugs, rifampicin, and semi-synthetic penicillin has a better efficacy than single application in treating severe infections resistant Gram-negative bacteria.

Precautions 1. Pregnant and lactating women, children, patients with severe kidneys damage and severe kidney dysfunction should either take with caution or reduce the administrated amount.
2. this product has relative large toxicity and a poor efficacy in treating deep tissue infection. It is also not the primary choice of drug for treating any kinds of infection.
3. intravenous injection may lead to respiratory depression and thus should generally not used. Half of the amount in daily dose should subject to intravenous drip, and can’t subject to disposable rapid bolus avoid extensive neuromuscular blockade.
4. it shouldn’t be used in combination with drugs with other renal toxicity or neuromuscular blocking effects to avoid accidents.
Uses Biochemical studies.
Polymyxin B is a kind of anti-Gram-negative poly-peptide antibiotics which can alter membrane structure allowing small molecules leakage and inhibit the growth of Gram-negative bacteria. It has bactericidal effect on Escherichia coli through binding to the lipid A portion of bacterial lipopolysaccharide. Mechanism of action: bind and interfere with the permeability o the cellular membrane. Anti-bacteria spectrum: gram negative bacteria.
Chemical Properties White Solid
Uses antibacterial
Uses Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mixtu re of Polymyxin B1 and B2 sulfate. Biological potency (dry basis): >6000U/mg.