Terlipressin acetate CAS NO.14636-12-5

Terlipressin acetate Basic information

Product Name:    Terlipressin acetate
Synonyms:    [N-α-Triglycyl-8-lysine]-vasopressin;130: PN: WO2010033207 SEQID: 171 claiMed protein;1-Triglycyl-8-lysine Vasopressin;Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin;Nα-Glycyl-glycyl-glycyl-lysine-vasopressin;Nα-Glycylglycylglycyl-vasopressin;Nα-Gly-Gly-Gly-8-Lys-vasopressin;Terlipressin, Terlipressine, Terlipressina, Terlipressinum
CAS:    14636-12-5
MF:    C52H74N16O15S2
MW:    1227.37
EINECS:    238-680-8
Product Categories:   
Mol File:    14636-12-5.mol

Terlipressin acetate Chemical Properties
Melting point     >170°C (dec.)
Boiling point     1824.0±65.0 °C(Predicted)
density     1.46±0.1 g/cm3(Predicted)
storage temp.     Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility     DMSO (Slightly), Methanol (Slightly)
pka    9.90±0.15(Predicted)
form     Solid
color     White
CAS DataBase Reference    14636-12-5(CAS DataBase Reference)

Chemical Properties    N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is White Solid
Uses    N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is used norepinephrine-resistant septic shock and hepatorenal syndrome. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is also used in the treatment of acute variceal bleeding.
Clinical Use    Treatment of bleeding oesophageal varices
Drug interactions    Potentially hazardous interactions with other drugs
None known
Metabolism    Terlipressin is metabolised by tissue peptidases resulting in the slow release of lypressin. Terlipressin is almost completely metabolised in the kidneys and liver, with less than 1% of terlipressin and less than 0.1% of lypressin excreted in the urine.