Sevelamer hydrochloride CAS NO.152751-57-0

Sevelamer hydrochloride Basic information

Product Name: Sevelamer hydrochloride
Synonyms: SEVELAMER HCL;Sevelemar;Sevelamer Hydrochloride;2-Propen-1-amine polymer with (chloromethyl)oxirane hydrochloride;(ChloroMethyl)oxirane polyMer with 2-Propen-1-aMine Hydrochloride;2-Propen-1-aMine Hydrochloride polyMer with 2-(ChloroMethyl)oxirane;AllylaMine Hydrochloride-epichlorohydrin CopolyMer;SevelaMer HCL API
CAS: 152751-57-0
MF: C6H12ClNO
MW: 149.61858 
EINECS: 
Product Categories: Pharmaceutical intermediate;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Other APIs
Mol File: 152751-57-0.mol

Originator    Renagel,Chugai Pharmaceutical
Uses    Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure.
Uses    Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease.
Manufacturing Process    Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w, 208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h and filtered to a 2500 L reactor. The transfer line was rinsed with water (217 kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for 1.5 h and then heated to reflux for 16 h. The resulting product slurry may be isolated and washed in decanter centrifuge.
Brand name    Renagel (Genzyme).
Therapeutic Function    Antihyperphosphatemic
Veterinary Drugs and Treatments    Sevalamer may be useful for treating hyperphosphatemia associated with chronic renal failure, particularly when oral aluminum salts are not tolerated.