TRIPELENNAMINE HYDROCHLORIDE CAS NO.154-69-8

Product Name:    TRIPELENNAMINE HYDROCHLORIDE
Synonyms:    2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinmonohydrochloride;2-ethanediamine,n,n-dimethyl-n’-(phenylmethyl)-n’-2-pyridinyl-monohydroc;2-(benzyl(2-(dimethylamino)ethyl)amino)pyridinemonohydrochloride;2-(benzyl(2-(dimethylamino)ethyl)amino)-pyridinhydrochloride;1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride;Ahistamin;Antiallergicum medivet;Ethylenediamine, N-benzyl-N',N'-dimethyl-N-(2-pyridyl)-, hydrochloride
CAS:    154-69-8
MF:    C16H22ClN3
MW:    291.82
EINECS:    205-833-5
Mol File:    154-69-8.mol             

Melting point     192-193℃
density     1.20
storage temp.     Keep in dark place,Inert atmosphere,Room temperature
form     neat
EPA Substance Registry System    Tripelennamine hydrochloride (154-69-8)
Safety Information
Hazard Codes     Xn
Risk Statements     22-36/37/38
Safety Statements     26-36
WGK Germany     3
RTECS     US3150000
HS Code     2933399090
Toxicity    LD50 in mice (mg/kg): 47 i.p. (Walker)
MSDS Information
Provider    Language
SigmaAldrich    English
TRIPELENNAMINE HYDROCHLORIDE Usage And Synthesis
Chemical Properties    White Solid
Uses    Tripelennamine is a first-generation antihistamine, used in the treatment of asthma, hay fever, and urticaria.
Uses    antihistaminic;histamine H1 antagonist
Brand name    PBZ (Novartis).
General Description    Tripelennamine hydrochlorideis a white crystalline powder that darkensslowly on exposure to light. The salt is soluble in water(1:0.77) and in alcohol (1:6). It has a pKa of about 9, and a0.1% solution has a pH of about 5.5.
Tripelennamine, the first ethylenediamine developed inthe United States and is well absorbed when given orally. Itappears to be as effective as diphenhydramine and may havethe advantage of fewer and less severe side reactions.Drowsiness may occur, however, and may impair the abilityto perform tasks requiring alertness. The concurrent use ofalcoholic beverages should be avoided.
General Description    Odorless white crystalline powder or solid. Bitter taste. Solutions are neutral to litmus. pH of aqueous solution (25 mg/mL): 6.71. pH of aqueous solution (50 mg/mL): 6.67. pH of aqueous solution (100 mg/mL): 5.56.
Air & Water Reactions    Water soluble.
Reactivity Profile    TRIPELENNAMINE HYDROCHLORIDE behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
Fire Hazard    Flash point data for TRIPELENNAMINE HYDROCHLORIDE are not available; however, TRIPELENNAMINE HYDROCHLORIDE is probably combustible.
Veterinary Drugs and Treatments    Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Tripelennamine has been used as a CNS stimulant in “Downer cows” when administered slow IV.