Propargyl-PEG5-amine CAS NO.1589522-46-2

Propargyl-PEG5-amine Basic information
Product Name:    Propargyl-PEG5-amine
Synonyms:    Propargyl-PEG5-amine;HC≡C-CH2-PEG6-NH2;Alkyne-PEG5-NH2;PROPARGYL-PEG5-NH2;3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine;Propargyl-PEG5-NH2/3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine;2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine
CAS:    1589522-46-2
MF:    C13H25NO5
MW:    275.34
EINECS:    
Product Categories:    PROTAC Linker;PROTAC;peg
Mol File:    1589522-46-2.mol

Propargyl-PEG5-amine Chemical Properties
Boiling point     360.4±37.0 °C(Predicted)
density     1.049±0.06 g/cm3(Predicted)
solubility     DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)
pka    8.74±0.10(Predicted)
form     Liquid
color     Colorless to light yellow

Propargyl-PEG5-amine Usage And Synthesis
Description    Propargyl-PEG5-amine is a propargyl linker that is commonly used as a Click Chemistry reagent for copper-catalyzed reactions with azides. The amine moiety reacts with carboxylic acids, activated NHS esters and other carbonyl compounds. The PEG spacer helps improve the water solubility of the molecule in aqueous media.
Biological Activity    Propargyl-PEG5-amine is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules.
in vitro    

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target    

Non-cleavable

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PEGs