- Product Details
Keywords
- Sodium 4-phenylbutyrate
- 1716-12-7
- 98% purity
Quick Details
- ProName: Sodium 4-phenylbutyrate
- CasNo: 1716-12-7
- Molecular Formula: C10H11NaO2
- Appearance: powder
- Application: intermediate
- DeliveryTime: in stock
- PackAge: accroding to the need
- Port: Shanghai Port
- ProductionCapacity: 100 Kilogram/Day
- Purity: 98% purity
- Storage: Sealed in dry,Room Temperature
- Transportation: air,sea and courier
- LimitNum: 1 Gram
- Grade: Industrial Grade,Pharma Grade,Electron...
Superiority
Product Name: Sodium 4-phenylbutyrate
Synonyms: SPB;SODIUM 4-PHENYLBUTYRATE;SODIUM PHENYLBUTYRATE;PBNA;PHENYL N-BUTYRATE SODIUM SALT;4-PHENYLBUTYRATE, NA;4-PHENYLBUTYRIC ACID SODIUM;4-PHENYLBUTYRIC ACID SODIUM SALT
CAS: 1716-12-7
MF: C10H11NaO2
MW: 186.18
EINECS: 605-612-7
Mol File: 1716-12-7.mol
Details
storage temp. room temp
solubility H2O: ≥5mg/mL
form White to slightly yellow solid
color white to beige
InChIKey OBKXEAXTFZPCHS-UHFFFAOYSA-N
CAS DataBase Reference 1716-12-7(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36
Safety Statements 26
WGK Germany 3
RTECS CY9057220
HS Code 29163990
MSDS Information
Sodium 4-phenylbutyrate Usage And Synthesis
Description Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.
Sodium phenylbutyrate stimulates urinary nitrogen excretion. It is a prodrug, which undergoes β-oxidation to phenylacetate. Sodium phenylbutyrate is used to treat urea cycle disorder. It might be associated with menstrual dysfunction, amenorrhea and painful mucositis of the esophagus and stomach.
Sodium phenylbutyrate has been used as an endoplasmic reticulum (ER) stress inhibitor to study the role of ER stress in the expression of betatrophin.
Chemical Properties White or yellowish-white powder.
Uses ACE inhibitor, antihypertensive, Inhibitor of histone deacetylase (HDAC). Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.
Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.
Definition ChEBI: The organic sodium salt of 4-phenylbutyric acid. A prodrug for phenylacetate, it is used to treat urea cycle disorders.
Brand name Buphenyl (Medicis).
Biological Activity Sodium 4-Phenylbutyrate is a histone deacetylase inhibitor that displays anticancer activity. Inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. Also inhibits protein isoprenylation, depletes plasma glutamine, increases production of fetal hemoglobin through transcriptional activation of the γ-globin gene and affects hPPARγ activation.