Oxytetracycline hydrochloride CAS NO.2058-46-0

Product Name: Oxytetracycline hydrochloride
Synonyms: 10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-monohydrochloride;2-naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,;5alpha,5aalpha,6beta,12aalpha)]-aalph;6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-,monohydrochloride,[4s-(4alpha,4;biosolvomycin;engemycin;hydrocyclin;liquamycininjectable
CAS: 2058-46-0
MF: C22H25ClN2O9
MW: 496.89
EINECS: 218-161-2
Product Categories: Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;L - ZEPA;NeatsAntibiotics;TetracyclinesMore...Close...;1694 Pharmaceuticals&Personal Care Products;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisSpectrum of Activity;Mechanism of Action;Pharmaceutical intermediate
Mol File: 2058-46-0.mol

mp  180°C
storage temp.  0-6°C
form  crystalline
color  yellow
Water Solubility  >100 g/L
Merck  13,7046
CAS DataBase Reference 2058-46-0(CAS DataBase Reference)
EPA Substance Registry System 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5, 5a,6,11,12a-octahydro-3,5, 6,10,12,12a-hexahydroxy-6- methyl-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,6S,12aS)-(2058-46-0)
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  63-36-36/37/38
Safety Statements  36/37/39-26-36-36/37
WGK Germany  2
RTECS  QI8225000
F  8-10-23
HS Code  29413000
 

Oxytetracycline hydrochloride Usage And Synthesis
Chemical Properties Yellow Crystalline Solid
Usage Antibiotic substance isolated from the elaboration products of the actinomycete, Streptomyces rimosus, grown on a suitable medium. Antibacterial
Usage Oxytetracycline hydrochloride is a salt prepared from oxytetracycline taking advantage of the basic dimethylamino group which protonates readily to form the salt in hydrochloric acid solutions. The hydrochloride is the preferred formulation for pharmaceutical applications. Like all tetracyclines, oxytetracycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal sub-units, blocking protein synthesis.
General Description Odorless fluffy yellow solid or yellow powder. Bitter taste.
Air & Water Reactions Oxytetracycline hydrochloride is hygroscopic. Water soluble. Undergoes slow hydrolysis in the presence of water. Concentrated aqueous solutions at neutral pH hydrolyze on standing.
Reactivity Profile Oxytetracycline hydrochloride is sensitive to light. Oxytetracycline hydrochloride may be unstable at temperatures above 77° F. Oxytetracycline hydrochloride darkens on exposure to sunlight or to moist air above 194° F. Concentrated aqueous solutions at neutral pH hydrolyze on standing. Oxytetracycline hydrochloride undergoes hydrolysis in the presence of water. Oxytetracycline hydrochloride may be incompatible with alkalis.
Fire Hazard Flash point data for Oxytetracycline hydrochloride are not available. Oxytetracycline hydrochloride is probably combustible.
Oxytetracycline hydrochloride Preparation Products And Raw materials
Raw materials Hydrochloric acid-->Methanol-->Sulfuric acid -->Activated carbon-->Oxytetracycline