Esomeprazole magnesium trihydrate CAS NO.217087-09-7

Esomeprazole magnesium trihydrate Basic information

Product Name:    Esomeprazole magnesium trihydrate
Synonyms:    ESOMEPRAZOLE MAGNESIUM TRIHYDRATE;bis(5-methoxy-2-[(s)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1h-benzylimidazole-1-yl) magnesium trihydrate;(T-4)-Bis[5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolato]magnesium;Nexium;ESOPMEPRAZOLE MG TRIHYDRATE;5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]benzimidazol-1-ide;5-methoxy-2-[(4-methoxy-3,5-dimethyl-pyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
CAS:    217087-09-7
MF:    C34H38MgN6O7S2
MW:    731.14
EINECS:    669-839-3
Product Categories:    Acid pump inhibitors;Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:    217087-09-7.mol
 

Esomeprazole magnesium trihydrate Chemical Properties
Melting point     184-189°C (dec.)
storage temp.     Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility     Slightly soluble in water, soluble in methanol, practically insoluble in heptane.
form     neat
InChIKey    VEVZQDGATGBLIC-UHFFFAOYSA-N
CAS DataBase Reference    217087-09-7(CAS DataBase Reference)

Safety Information
Hazard Codes     Xn
Risk Statements     22
WGK Germany     3
HS Code     2933399090

MSDS Information
Esomeprazole magnesium trihydrate Usage And Synthesis
Chemical Properties    Off-White Powder
Uses    S-Form of Omeprazole. Gastric proton-pump inhibitor
Uses    esomeprazole magnesium trihydrate for the healing of peptic ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.
Zollinger-Ellison syndrome
Peptic ulcer, site unspecified
Duodenal ulcer
Gastric ulcer
Gastro-oesophageal reflux disease
Esomeprazole belongs to the family of medications known as proton pump inhibitors (PPIs). Esomeprazole is registered by the Therapeutic Goods Administration (TGA) for the following indications:
Gastro-Oesophageal Reflux Disease (GORD):
treatment of erosive reflux oesophagitis;
long-term management of patients with healed oesophagitis to prevent relapse;
symptomatic treatment of gastro-oesophageal reflux disease (GORD).
In combination with appropriate antibiotics for:
healing of duodenal ulcer associated with Helicobacter pylori;
eradication of Helicobacter pylori in patients with active or healed peptic ulcer.
Short-term treatment of upper gastrointestinal symptoms associated with non-steroidal anti-inflammatory drug (NSAID) (non-selective and COX-2 selective) therapy.
Healing of gastric ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy.
Prevention of gastric and duodenal ulcers associated with non-steroidal anti-inflammatory drug NSAID (non-selective and COX-2 selective) therapy in patients at risk.
Uses    Esomeprazole Magnesium Trihydrate is used in preparation of esomeprazole magnesium trihydrate.
Brand name    Nexium (AstraZeneca).