SB 431542 CAS NO.301836-41-9

Product Name:    SB 431542
Synonyms:    SB-431542/SB431542;SB 431542, >=98%;4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide SB431542;SB 431542 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide;4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate;SB 431542;4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE;4-[4-(3,4-METHYLENEDIOXYPHENYL)-5-(2-PYRIDYL)-1H-IMIDAZOL-2-YL]-BENZAMIDE
CAS:    301836-41-9
MF:    C22H16N4O3
MW:    384.39
EINECS:     
Mol File:    301836-41-9.mol
 

Melting point     214 °C(dec.)
Boiling point     662.4±55.0 °C(Predicted)
density     1.373
Fp     354.4℃
storage temp.     Sealed in dry,Store in freezer, under -20°C
solubility     DMSO: 10 mg/mL, soluble
pka    10.14±0.10(Predicted)
form     powder
InChIKey    FHYUGAJXYORMHI-UHFFFAOYSA-N
Safety Information
Safety Statements     22-24/25
WGK Germany     3
HS Code     29349990
MSDS Information
SB 431542 Usage And Synthesis
Uses    SB 431542 is a known Src family kinase inhibitor that effectively blocks the transforming growth factor-β1-induced cell migration and invasion in both established and primary carcinoma cells.
Definition    ChEBI: A member of the class of benzamides that is 4-(imidazol-2-yl)benzamide carrying additional 1,3-benzodioxol-5-yl and pyridin-2-yl substituents at positions 4 and 5 respectively on the imidazole ring.
Biological Activity    Potent and selective inhibitor of the transforming growth factor- β (TGF- β ) type I receptor activin receptor-like kinase ALK5 (IC 50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF- β -induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells.