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Pyroxamide CAS NO.382180-17-8
- Min.Order: 1 Gram
- Payment Terms: T/T,Other
- Product Details
Keywords
- Pyroxamide
- 382180-17-8
- 98% purity
Quick Details
- ProName: Pyroxamide
- CasNo: 382180-17-8
- Molecular Formula: C13H19N3O3
- Appearance: powder
- Application: intermediate
- DeliveryTime: in stock
- PackAge: accroding to the need
- Port: Shanghai Port
- ProductionCapacity: 100 Kilogram/Day
- Purity: 98% purity
- Storage: Sealed in dry,Room Temperature
- Transportation: air，sea and courier
- LimitNum: 1 Gram
- Grade: Industrial Grade,Pharma Grade,Electron...
Superiority
Product Name: Pyroxamide
Synonyms: 382180-17-8; NSC-696085; N-HYDROXY-N'-3-PYRIDINYLOCTANEDIAMIDE; N-HYDROXY-N'-(PYRIDIN-3-YL)OCTANEDIAMIDE; NSC696085; NSC 696085;n-hydroxy-n'-(pyridin-3-yl)octanediamide;NSC 696085;Pyroxamide ;2-[1-carbaMoyl-N-(2H-pyran-2-yl)forMaMido]-N-hydroxy-N'-(pyridin-3-yl)octanediaMide;PyroxaMide (NSC 696085);N1-Hydroxy-N8-3-pyridinyl-octanediamide;N1-Hydroxy-N8-(pyridin-3-yl)octanediamide
CAS: 382180-17-8
MF: C13H19N3O3
MW: 265.31
EINECS:
Product Categories:
Mol File: 382180-17-8.mol
Details
storage temp. -20°C
solubility DMSO: soluble10mg/mL (clear solution)
form powder
color white to beige
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
Pyroxamide Usage And Synthesis
Uses Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes imp licated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
Uses Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.