Taurohyodeoxycholic acid sodium salt hydrate CAS NO.38411-85-7

Taurohyodeoxycholic acid sodium salt hydrate Basic information
Product Name:    Taurohyodeoxycholic acid sodium salt hydrate
Synonyms:    Taurohyodeoxycholic acid sodium salt hydrate;Taurohyodeoxycholic acid hydrate sodium salt;Sodium taurohyodeoxycholate hydrate,Taurohyodeoxycholic acid sodium salt hydrate
CAS:    38411-85-7
MF:    C26H46NNaO6S
MW:    523.7
Mol File:    38411-85-7.mol

Description    Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid . THDCA decreases the size and weight of human gallstones in vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats. Co-administration of THDCA with taurochenodeoxycholic acid (TCDCA; ) prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats. THDCA also reduces myeloperoxidase activity, expression of TNF-α and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis.
Uses    Sodium taurohyodeoxycholate hydrate has been used in a study to assess dose-response data for cytotoxicity, regenerative cell proliferation and secondary oxidative DNA damage in rat livers treated with furan. It has also been used in a study to investigate the use of an immobilized artificial membrane HPLC column to predict bile salt-membrane interactions.
General Description    Sodium taurohyodeoxycholate hydrate is a taurine-amidated bile salt, which can be used as an anionic detergent.