L-5-HYDROXYTRYPTOPHAN 4350-09-8 large in supply CAS NO.4350-09-8

Synonyms: 5-hydroxy-l-tryptopha;pretonine;C5-HYDROXY-L-TRYPTOPHAN;H-5-HYDROXY-TRP-OH;H-TRP(5-OH)-OH;L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;L-5-HYDROXYTRYPTOPHAN HYDRATE;L-5-HYDROXYTRYPTOPHAN
CAS: 4350-09-8, 314062-44-7
MF: C11H12N2O3
MW: 220.22
EINECS: 224-411-1
Product Categories: Pharmaceutical Raw Materials;Indoles and derivatives;Tryptophan [Trp, W];Amino Acids;Biochemistry;Biological-modified Amino Acids;Indoles;Tryptophans;Natural Plant Extract;Amino acidsPeptide Synthesis;Biochemicals Found in Plants;Nutrition Research;Tryptophan Derivatives;Unnatural Amino Acid Derivatives;Amines;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals;Amines, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;amino;Other APIs;natural product;Inhibitors
Mol File: 4350-09-8.mol
L-5-Hydroxytryptophan Structure
L-5-Hydroxytryptophan Chemical Properties
Melting point  270 °C (dec.)(lit.)
alpha  -32.5 º (c=1,H2O on dry basis)
density  0.902 g/mL at 25 °C(lit.)
refractive index  n20/D 1.4850(lit.)
Fp  175 °F
storage temp.  2-8°C
solubility  H2O: 10 mg/mL
form  solid
color  white
Water Solubility  Slightly soluble
Merck  14,4847
BRN  88200
CAS DataBase Reference 4350-09-8(CAS DataBase Reference)
EPA Substance Registry System L-Tryptophan, 5-hydroxy-(4350-09-8)
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-65-20/21/22-20/21
Safety Statements  36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  YN7110000
F  3-10
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29339990

【Synonyms】

(2S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid
L-5-Hydroxytryptophan
Levothym
Oxitriptan
Pretonine
Quietim
【CAS】

4350-09-8
【Formula】

C11H12N2O3
【Molecular Weight】

220.23
【EINECS】

224-411-1
【RTECS】

YN7110000
【RTECS Class】

Drug; Reproductive Effector
【Merck】

12,4895
【Beilstein/Gmelin】

88200
【Beilstein Reference】

5-22-14-00278
【EC Class】

harmful
Physical and Chemical Properties Back to Contents
【Appearance】

Colorless to pale pink crystals.
【Solubility in water】

Very soluble
【Melting Point】

273
【pKa/pKb】

2.22 (pKa)
【Usage】

Marketed as a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid.
【Vapor Density】

7.59
First Aid Measures Back to Contents
【Ingestion】

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】

Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
【Skin】

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Handling and Storage Back to Contents
【Storage】

Store in a tightly closed container. Refrigerator (approx 4 C). Store in a cool, dry area away from incompatible substances.
【Handling】

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale.
Hazards Identification Back to Contents
【Ingestion】

Harmful if swallowed. May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
【Inhalation】

May cause respiratory tract irritation. May cause irritation of the mucous membranes.
【Skin】

May cause skin irritation.
【Eyes】

May cause eye irritation.
【EC Risk Phrase】

R 22
【EC Safety Phrase】

S 22 36/37
Exposure Controls/Personal Protection Back to Contents
【Personal Protection】

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Fire Fighting Measures Back to Contents
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Accidental Release Measures Back to Contents
【Small spills/leaks】

Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
Stability and Reactivity Back to Contents
【Disposal Code】

3
【Stability】

Stable under normal temperatures and pressures.
【Incompatibilities】

Strong oxidizing agents.
【Decomposition】

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Transport Information Back to Contents
【HS Code】

2933 99 90