Genistein 446-72-0 Large in promotion CAS NO.446-72-0

Genistein Basic information

Product Name: Genistein
Synonyms: 4’,5,7-trihydroxy-isoflavon;5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;c.i.75610;differenola;genistein(synthetic);genisteol;genisterin;prunetol
CAS: 446-72-0
MF: C15H10O5
MW: 270.24
EINECS: 207-174-9
Product Categories: pharmacetical;Biochemistry;Flavonoids;Natural Plant Extract;The group of Daidzin;Inhibitors;Tyrosine Kinase Inhibitors;Protein Kinase;Signalling;Plant extract;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;inhibitor
Mol File: 446-72-0.mol

Genistein Chemical Properties

mp  297-298 °C 
storage temp.  −20°C

solubility  DMSO: soluble

form  powder

color  off-white

Water Solubility  insoluble
Merck  14,4391
BRN  263823
Stability: Light Sensitive
CAS DataBase Reference 446-72-0(CAS DataBase Reference)
EPA Substance Registry System 4H-1-Benzopyran- 4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)- (446-72-0)

Safety Information

Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-24/25-22
WGK Germany  3

RTECS  NR2392000

HazardClass  IRRITANT
Hazardous Substances Data 446-72-0(Hazardous Substances Data)

Genistein Usage And Synthesis

Chemical Properties Yellow Crystalline Solid
Usage Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
Usage Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
Usage cytotoxic inhibitor of tyrosine kinase and topoisomerase II kinase
Biological Activity Phytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPAR γ and estrogen receptors and acts as an agonist at GPR30. Also available as part of the MAPK Cascade Inhibitor Tocriset™ .

Genistein Preparation Products And Raw materials

Raw materials Diethyl ether