China (Mainland)
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Prostigmin methyl sulfate CAS NO.51-60-5
- Min.Order: 1 Metric Ton
- Payment Terms: T/T
- Available Specifications:
- Product Details
Keywords
- Prostigmin methyl sulfate
- Benzenaminium,3-[[(dimethylamino)carbonyl]- oxy]-N,N,N-trimethyl-,methyl sulfate
- AR-32
Quick Details
- ProName: 3-[[(Dimethylamino)carbonyl]oxy]-N,N,N...
- CasNo: 51-60-5
- Molecular Formula: C13H22N2O6S
- Appearance: powder
- Application: The methylsulfate salt is used postope...
- DeliveryTime: in stock
- PackAge: according to the customer
- Port: shanghai
- ProductionCapacity: 100 Metric Ton/
- Purity: 99%
- Storage: -20°C
- Transportation: by air sea or courier
- LimitNum: 1 Metric Ton
- 1: 1
- 1: 1
Superiority
The methylsulfate salt is used postoperatively as a urinarystimulant and in the diagnosis and treatment of myastheniagravis.
Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM). In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively). Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block. Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.
Details
Neostigmine methylsulfate,(m-hydroxyphenyl)trimethylammonium methylsulfatedimethylcarbamate or the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniummethylsulfate (Prostigminmethylsulfate), is a bitter, odorless, white, crystalline powder.It is very soluble in water and soluble in alcohol. Solutionsare stable and can be sterilized by boiling. The compound istoo hygroscopic for use in a solid form and thus is alwaysused as an injection. Aqueous solutions are neutral to litmus.