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Home > Products >  TETRAHYDROZOLINE HCL

TETRAHYDROZOLINE HCL CAS NO.522-48-5

  • Min.Order: 1 Gram
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  • Product Details

Keywords

  • TETRAHYDROZOLINE HCL
  • 522-48-5
  • 98% purity

Quick Details

  • ProName: TETRAHYDROZOLINE HCL
  • CasNo: 522-48-5
  • Molecular Formula: C13H17ClN2
  • Appearance: powder
  • Application: intermediate
  • DeliveryTime: in stock
  • PackAge: accroding to the need
  • Port: Shanghai Port
  • ProductionCapacity: 100 Kilogram/Day
  • Purity: 98% purity
  • Storage: Sealed in dry,Room Temperature
  • Transportation: air,sea and courier
  • LimitNum: 1 Gram

Superiority

Product Name:    2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride
Synonyms:    2-(1,2,3,4-Tetrahydro-1-Naphthylamino)-2-ImidazolineHydrochloride;Tetrahydrozline;TETRAHYDROZOLINEHYDROCHLORIDE,USP;2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride;2-(1,2,3,4-Tetrahydronaphthalene-1-yl)-4,5-dihydro-1H-imidazole·hydrochloride;Tetrahydrozoline hyrdrochloride;Tetrahydrozoline·hydrochloric acid;Tetrahydrozoline Hydrochloride (200 mg)
CAS:    522-48-5
MF:    C13H17ClN2
MW:    236.74
EINECS:    208-329-3          
Mol File:    522-48-5.mol

Details

2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Chemical Properties
Melting point     248-251°C
storage temp.     Inert atmosphere,Room Temperature
solubility     H2O: freely soluble
form     neat
InChIKey    BJORNXNYWNIWEY-UHFFFAOYSA-N
CAS DataBase Reference    522-48-5(CAS DataBase Reference)
EPA Substance Registry System    1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochloride (522-48-5)
Safety Information
Hazard Codes     Xn,Xi
Risk Statements     22-36/37/38
Safety Statements     26-36
WGK Germany     3
RTECS     NJ4550000
HS Code     2933290000
MSDS Information
Provider    Language
SigmaAldrich    English
2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Usage And Synthesis
Chemical Properties    Off-White Solid
Originator    Tyzine,Pfizer,US,1954
Uses    adrenergic agonist, nasal decongestant
Uses    2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride is an alpha agonist, causing constriction of conjunctival blood vessels,it is used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.
Manufacturing Process    A mixture of 540 grams (9.0 mols) of ethylenediamine, 270 grams (1.53 mols) of 1,2,3,4tetrahydro-α-naphthoic acid, and 360 ml (4.32 mols) of concentrated hydrochloric acid was introduced into a two-liter, three-necked flask fitted with a thermometer, stirrer, and distillation takeoff. The mixture was distilled under a pressure of about 20 mm of mercury absolute until the temperature rose to 210°C. Thereafter, heating was continued under atmospheric pressure and when the temperature reached about 260°C, an exothermic reaction was initiated. The heat was then adjusted to maintain a reaction temperature of 275° to 280°C for 45 minutes and the mixture thereafter cooled to room temperature.
900 ml of 4 N hydrochloric acid was added and the aqueous layer stirred with warming until a clear, brown solution resulted. This brown solution was made strongly alkaline with sodium hydroxide. The oil that separated solidified and was collected on a filter leaving filtrate A. The solid was dissolved in 370 ml of alcohol with warming, and the solution was treated with 130 ml of concentrated hydrochloric acid with stirring and cooling. This acidified mixture was diluted with 300 ml of ether and chilled. The solid salt was collected and dried and the filtrate concentrated to approximately 300 ml, diluted with 300 ml of ether and the salt which separated collected and dried.
Filtrate A was extracted with ether, dried, acidified with alcoholic hydrogen chloride, and the salt which separated was collected and dried. There was thus obtained, when all the salt had been combined, 250 grams (69.3% of the theoretical yield) of 2-(1,2,3,4-tetrahydro-1-naphthyl)imidazoline hydrochloride, melting at 256° to 257°C.
Brand name    Tetryzo- line is INN and BAN; Tetryzoline Hydrochloride is JAN; Tetrahydrozoline Nitrate is JAN.
Therapeutic Function    Nasal decongestant, Pharmaceutic aid
2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride Preparation Products And Raw materials
Raw materials    Hydrochloric acid-->Ethylenediamine-->Azelastine hydrochloride

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