2-Thiophenecarboxylic acid CAS NO.527-72-0

Product Name:    2-Thiophenecarboxylic acid
Synonyms:    2-Thenoic Acid 2-Thiophenic Acid Thiophene-2-carboxylic acid;LABOTEST-BB LT02016392;AKOS B022791;AKOS BBS-00003739;ALPHA-THENOIC ACID;2-THENOIC ACID;2-THIOPHENIC ACID;2-THIOPHENECARBOXYLIC ACID
CAS:    527-72-0
MF:    C5H4O2S
MW:    128.15
EINECS:    208-423-4           
Mol File:    527-72-0.mol                                                     

2-Thiophenecarboxylic acid Chemical Properties
Melting point     125-127 °C(lit.)
Boiling point     260 °C(lit.)
density     1.42
refractive index     1.5160 (estimate)
Fp     259-261°C
storage temp.     Keep in dark place,Sealed in dry,Room Temperature
form     solid
pka    3.49(at 25℃)
Water Solubility     80 g/L (20 ºC)
Merck     14,9354
BRN     110150
InChIKey    QERYCTSHXKAMIS-UHFFFAOYSA-N
CAS DataBase Reference    527-72-0(CAS DataBase Reference)
NIST Chemistry Reference    2-Thiophenecarboxylic acid(527-72-0)
EPA Substance Registry System    2-Thiophenecarboxylic acid (527-72-0)
Safety Information
Hazard Codes     Xi
Risk Statements     36/37/38
Safety Statements     26-36-37/39
WGK Germany     3
RTECS     XM8330200
Hazard Note     Irritant
TSCA     Yes
HS Code     29349990
MSDS Information
Provider    Language
Thiophene-2-carboxylic acid    English
SigmaAldrich    English
ACROS    English
ALFA    English
2-Thiophenecarboxylic acid Usage And Synthesis
Uses    2-Thenoic Acid, is a sulfur-containing heterocyclic compound, used in the synthesis of pharmaceutical and biologically active compounds. It is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.
Chemical Properties    white to light yellow crystal powder
Definition    ChEBI: A thiophenecarboxylic acid in which the carboxy group is located at position 2.
Synthesis Reference(s)    The Journal of Organic Chemistry, 30, p. 3520, 1965 DOI: 10.1021/jo01021a055
Purification Methods    Crystallise the acid from water and dry it in a vacuum. The amide has m 181o(from H2O) and pK2 5 10.54(50% aqueous dioxane). [Beilstein 18 H 289, 18 I 438, 18 II 269, 18 III/IV 4011, 18/6 V 158.]
2-Thiophenecarboxylic acid Preparation Products And Raw materials
Raw materials    2-Bromothiophene-->CARBON DIOXIDE
Preparation Products    3-(THIOPHEN-2-YL)ISOXAZOL-5-AMINE-->3-BROMOTHIOPHENE-2-CARBOXAMIDE-->7-DIETHYLAMINO-3-THENOYLCOUMARIN-->BIS(2-THIENYL) KETONE-->5-BROMOTHIOPHENE-2-CARBONITRILE-->2-THIOPHENAMINE-->5-TERT-BUTYL-THIOPHENE-2-CARBOXYLIC ACID-->5-Nitrothiophene-2-carboxylic acid-->2-(Chloromethyl)thiophene-->5-Bromo-2-thiophenecarboxylic acid-->2-THIOPHENECARBOXYLIC ACID SODIUM SALT-->CIS-3-PENTEN-1-OL-->Methyl 4,5-dichlorothiophene-2-carboxylate-->2-Thienylmethanethiol-->5-Amino-thiophene-2-carboxylic acid methyl ester-->TRANS-2-PENTEN-1-OL