Thiabendazole CAS NO.53-86-1

Indometacin Basic information

Product Name: Indometacin
Synonyms: AURORA KA-6542;INDOCIN;INDOMETACIN;INDOMETACINE;INDOMETHACIN;INDOMETHACINE;LABOTEST-BB LT00244830;1-(P-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
CAS: 53-86-1
MF: C19H16ClNO4
MW: 357.79
EINECS: 200-186-5
Product Categories: PHARMACEUTICALS;Active Pharmaceutical Ingredients;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Lipid signaling;INDOCIN;Other APIs              
Mol File: 53-86-1.mol            

Indometacin Chemical Properties

mp  155-162 °C
storage temp.  Store at RT
solubility  ethanol: 50 mg/mL, clear, yellow-green
Merck  4968
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 53-86-1(CAS DataBase Reference)
NIST Chemistry Reference Indomethacin(53-86-1)
EPA Substance Registry System 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-(53-86-1)

Safety Information

Hazard Codes  T+,Xi
Risk Statements  28-36/37/38
Safety Statements  28-36/37-45-36-26
RIDADR  UN 2811 6.1/PG 
WGK Germany  
RTECS  NL3500000
F  8-10       
HazardClass  6.1
PackingGroup  I
Hazardous Substances Data 53-86-1(Hazardous Substances Data)

Indometacin Usage And Synthesis

Chemical Properties Crystalline Solid
Usage Inhibits cyclooxygenase (IC50=0.1uM) selectively over liposygenases (IC50=100uM for 5-,12- and 15-LO). A clinically useful NAISD
Usage antiinflammatory, antipyretic, analgesic
General Description Crystals.
Air & Water Reactions Practically insoluble in water. Decomposes in alkali.
Reactivity Profile A weak organic acid.
Fire Hazard Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
Biological Activity Cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC 50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.