2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl CAS NO.657408-07-6

Product Name:    2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
Synonyms:    98% SPhos;2-Dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl ,98%;2-Dicyclohexylphosphino-2', 6-diMethoxybihenyl;2-DicyclohexylphosphiNA-2',6'-diMethoxybiphenyl;Dicyclohexyl(2',6'-diMethoxy-[1,1'-biphenyl]-2-yl)phosphine;SPhos 97%;2-Dicyclohexylphosphino-2',6'-diMethoxybiphenyl, 6'-diMethoxybiphenyl;2 - dicyclohexyl phosphine - 2 ', 6 '- diMethoxy - 1, 1' - two PCB
CAS:    657408-07-6
MF:    C26H35O2P
MW:    410.53
EINECS:    613-838-2
Product Categories:    Phosphines;Achiral Phosphine;Aryl Phosphine;Buchwald Ligands Series;Buchwald Ligands&Precatalysts
Mol File:    657408-07-6.mol

Melting point     164-166°C
Boiling point     513.3±40.0 °C(Predicted)
storage temp.     Refrigerated.
form     crystal
color     white
Sensitive     Air Sensitive
InChIKey    VNFWTIYUKDMAOP-UHFFFAOYSA-N
Safety Information
Hazard Codes     Xn
Risk Statements     40
Safety Statements     24/25-36/37
WGK Germany     3
TSCA     No
MSDS Information
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Usage And Synthesis
Uses    SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. 
SPhos may be used as a ligand in the following processes:
• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.• Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation.
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.
Reactions    
Ligand/palladium catalyst for general Suzuki-Miyaura cross-coupling reactions.
Ligand/palladium catalyst for the Suzuki-Miyaura coupling of aryltrifluoroborates with aryl chlorides.
Ligand/palladium catalyst for the Suzuki-Miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.
Ligand/palladium catalyst for the Kumada-Corriu cross-coupling reaction.
Ligand/palladium catalyst for the borylation of aryl halides with pinacol borane.
Suzuki couplings involving amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenyl glycine, tyrosine and tryptophan.
Synthesis of substituted adamantylzinc reagents using Mg-insertion in the presence of zinc chloride.
Highly efficient catalyst for the palladium-catalyzed Suzuki-Miyura reaction of heteroaryl halides and heteroaryl boronic acids

Chemical Properties    White solid
Uses    suzuki reaction
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Preparation Products And Raw materials
Raw materials    Ethyl acetate-->Tetrahydrofuran-->PETROLEUM ETHER-->n-Butyllithium-->Magnesium-->Dimethoxybenzene-->1,2-Dibromobenzene-->Dicyclohexylchlorophosphine

Product Name:    2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl
Synonyms:    98% SPhos;2-Dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl ,98%;2-Dicyclohexylphosphino-2', 6-diMethoxybihenyl;2-DicyclohexylphosphiNA-2',6'-diMethoxybiphenyl;Dicyclohexyl(2',6'-diMethoxy-[1,1'-biphenyl]-2-yl)phosphine;SPhos 97%;2-Dicyclohexylphosphino-2',6'-diMethoxybiphenyl, 6'-diMethoxybiphenyl;2 - dicyclohexyl phosphine - 2 ', 6 '- diMethoxy - 1, 1' - two PCB
CAS:    657408-07-6
MF:    C26H35O2P
MW:    410.53
EINECS:    613-838-2
Product Categories:    Phosphines;Achiral Phosphine;Aryl Phosphine;Buchwald Ligands Series;Buchwald Ligands&Precatalysts
Mol File:    657408-07-6.mol

Melting point     164-166°C
Boiling point     513.3±40.0 °C(Predicted)
storage temp.     Refrigerated.
form     crystal
color     white
Sensitive     Air Sensitive
InChIKey    VNFWTIYUKDMAOP-UHFFFAOYSA-N
Safety Information
Hazard Codes     Xn
Risk Statements     40
Safety Statements     24/25-36/37
WGK Germany     3
TSCA     No
MSDS Information
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Usage And Synthesis
Uses    SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. 
SPhos may be used as a ligand in the following processes:
• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.• Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.• Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Utilized in conjunction with palladium to form a highly active catalyst for C-N bond formation.
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.
Reactions    
Ligand/palladium catalyst for general Suzuki-Miyaura cross-coupling reactions.
Ligand/palladium catalyst for the Suzuki-Miyaura coupling of aryltrifluoroborates with aryl chlorides.
Ligand/palladium catalyst for the Suzuki-Miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.
Ligand/palladium catalyst for the Kumada-Corriu cross-coupling reaction.
Ligand/palladium catalyst for the borylation of aryl halides with pinacol borane.
Suzuki couplings involving amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenyl glycine, tyrosine and tryptophan.
Synthesis of substituted adamantylzinc reagents using Mg-insertion in the presence of zinc chloride.
Highly efficient catalyst for the palladium-catalyzed Suzuki-Miyura reaction of heteroaryl halides and heteroaryl boronic acids

Chemical Properties    White solid
Uses    suzuki reaction
2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl Preparation Products And Raw materials
Raw materials    Ethyl acetate-->Tetrahydrofuran-->PETROLEUM ETHER-->n-Butyllithium-->Magnesium-->Dimethoxybenzene-->1,2-Dibromobenzene-->Dicyclohexylchlorophosphine