China (Mainland)
Assessedsupplier
Pyronaridine CAS NO.74847-35-1
- Min.Order: 1 Gram
- Payment Terms: T/T
- Available Specifications:
- Product Details
Keywords
- Benzo[b]-1,5-naphthyridine,phenol deriv.
- Malaridine
- Pyronaridine
Quick Details
- ProName: Pyronaridine
- CasNo: 74847-35-1
- Molecular Formula: C29H32ClN5O2
- Appearance: Solid
- DeliveryTime: in stock
- PackAge: according to the customer
- Port: shanghai
- ProductionCapacity: 100 Metric Ton/
- Purity: 99%
- Storage: Incompatible with strong oxidizing age...
- Transportation: by sea air or courier
- LimitNum: 1 Gram
- 1: 1
- 1: 1
Superiority
Pyronaridine is active against the asexual erythrocytic stage of P. falciparum with little or no activity against gametocytes or the hepatic stage. In-vitro blood schizonticide activities are in the range of 0.001–0.03 mg/L, showing a moderate correlation to chloroquine resistance. However, this correlation varies between studies and does not seem to be clinically significant. It is also active against P. vivax, P. ovale and P. malariae. Antagonistic interactions with artemisinins were reported in vitro, but synergy with artesunate has been observed in rodent models.
Details
Peak plasma concentrations are reached after 3–14 h depending upon the formulation; there is also considerable interindividual variation. Elimination half-lives of 63–190 h have been reported, again dependent upon the formulation.
Pyronaridine is active against the asexual erythrocytic stage of P. falciparum with little or no activity against gametocytes or the hepatic stage. In-vitro blood schizonticide activities are in the range of 0.001–0.03 mg/L, showing a moderate correlation to chloroquine resistance. However, this correlation varies between studies and does not seem to be clinically significant. It is also active against P. vivax, P. ovale and P. malariae. Antagonistic interactions with artemisinins were reported in vitro, but synergy with artesunate has been observed in rodent models.