Nafarelin CAS NO.76932-56-4

Uses Narfarrelin is used for the treatment of endometriosis, inflammation and cysts. Its role is mainly through inhibiting the hypothalamic-pituitary-ovarian axis, resulting in a low estrogen state in the body and causing ectopic endometrium atrophy. In addition, nafarelline can also be used to treat central precocious puberty. Endometriosis is an estrogen-dependent disease in which ovarian hormones are necessary for ectopic endometrial growth. Chemical properties NafarelinMonoacetate: C66883N17O13 C2H4O2. Crystallization, melting point 188 ~ 190℃. ^[α]D25-27.4°(C=0.9, ethylchemicalbook acid). It is an analogue of gonadotropin-releasing hormone (GnRH). Used in the treatment of endometriosis, can eliminate pain, reduce endometrial damage. Production method N-acetyl-2-cyanoglycine ethyl ester is reacted with 2-bromomethylnaphthalene in ethanol and then acid hydrolyzed to obtain compound (I). (Ⅰ) is first acetylated and then ester with methanol to produce compound (Ⅱ). (Ⅱ) The D-configuration (Ⅲ) was obtained by separation, and then the compound (Ⅳ) was obtained by hydrolysis with 6mol/L hydrochloric acid. (Ⅳ) was converted into N-tert-butoxycarbonyl derivative (V), which was synthesized by solid phase method on diphenylmethylamine resin.

Uses Narfarrelin is used for the treatment of endometriosis, inflammation and cysts. Its role is mainly through inhibiting the hypothalamic-pituitary-ovarian axis, resulting in a low estrogen state in the body and causing ectopic endometrium atrophy. In addition, nafarelline can also be used to treat central precocious puberty. Endometriosis is an estrogen-dependent disease in which ovarian hormones are necessary for ectopic endometrial growth. Chemical properties NafarelinMonoacetate: C66883N17O13 C2H4O2. Crystallization, melting point 188 ~ 190℃. ^[α]D25-27.4°(C=0.9, ethylchemicalbook acid). It is an analogue of gonadotropin-releasing hormone (GnRH). Used in the treatment of endometriosis, can eliminate pain, reduce endometrial damage. Production method N-acetyl-2-cyanoglycine ethyl ester is reacted with 2-bromomethylnaphthalene in ethanol and then acid hydrolyzed to obtain compound (I). (Ⅰ) is first acetylated and then ester with methanol to produce compound (Ⅱ). (Ⅱ) The D-configuration (Ⅲ) was obtained by separation, and then the compound (Ⅳ) was obtained by hydrolysis with 6mol/L hydrochloric acid. (Ⅳ) was converted into N-tert-butoxycarbonyl derivative (V), which was synthesized by solid phase method on diphenylmethylamine resin.