TRIS 77-86-1 most competitive in China market CAS NO.77-86-1

Product Name: Tris Base
Synonyms: 1,1,1-tris(hydroxymethyl)-methanamin;1,1,1-tris(hydroxymethyl)-methylamin;1,1,1-tris(hydroxymethyl)methylamine;1,3-Propanediol,2-amino-2-(hydroxymethyl)-;2-amino-2-(hydroxymethyl)-3-propanediol;2-Amino-2-hydroxymethylpropanediol;2-Amino-2-methylol-1,3-propanediol;3-Propanediol,2-amino-2-(hydroxymethyl)-1
CAS: 77-86-1
MF: C4H11NO3
MW: 121.14
EINECS: 201-064-4
Product Categories: Biochemistry;Reagents for Electrophoresis;Buffer;ACS Grade Buffers;Amino Alcohols;Biological Buffers;Buffers A to Z;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;API;Pharmaceutical intermediates;#N/A
Mol File: 77-86-1.mol
Tris Base Structure
Tris Base Chemical Properties
Melting point  167-172 °C(lit.)
Boiling point  219-220 °C10 mm Hg(lit.)
density  1,353 g/cm3
Fp  219-220°C/10mm
storage temp.  2-8°C
solubility  H2O: 4 M at 20 °C, clear, colorless
form  crystalline
color  white
PH 10.5-12.0(4 m in water, 25 °C)
pka 8.1(at 25℃)
Water Solubility  550 g/L (25 ºC)
Sensitive  Hygroscopic
Merck  14,9772
BRN  741883
Stability: Stable. Incompatible with bases, strong oxidizing agents. Protect from moisture.
CAS DataBase Reference 77-86-1(CAS DataBase Reference)
NIST Chemistry Reference 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-(77-86-1)
EPA Substance Registry System 1,3-Propanediol, 2-amino-2-(hydroxymethyl)- (77-86-1)
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39-24/25-23
WGK Germany  2
RTECS  TY2900000
F  3
TSCA  Yes
HazardClass  IRRITANT
HS Code  29221980
Hazardous Substances Data 77-86-1(Hazardous Substances Data)

Chemical Properties White crystal or powder. Melting point 171-172℃, boiling point 219-220℃/1.3kPa, soluble in ethanol and water, slightly soluble in ethyl acetate, benzene, insoluble in ether, carbon tetrachloride,copper,aluminum corrosion effects,irritant.
Uses of Biology Tris base, also known as THAM, is widely used as a biological buffer or as a component of buffer formulations such as TAE and TBE buffers. Tris has a pKa of 8.06 and is very useful in the biology and biochemistry lab because it has buffering capabilities in the range of the typical physiological pH of most living organisms (pH 7.0-9.0). Tris has been reported to interfere with the activity of a number of enzymes, it should therefore be used carefully when studying proteins.
Uses 1, Tris buffer, only nucleic acids and proteins are widely used as solvents.
2, Tris is used for protein crystal growth under different pH conditions.
3, Tris buffer having a low ionic strength can be used nematode (C. elegans) is formed lamin (lamin) intermediate fibers.
4, Tris is a major component of protein electrophoresis buffer.
5, Tris for the preparation of a surfactant, a vulcanization accelerator, and some drug intermediates.
6, Tris titrated also used as standard.
Chemical Properties White crystalline powder
Biological Activity Commonly used laboratory reagent