Methylparaben 99-76-3 purity 99% CAS NO.99-76-3

Synonyms: NIPAGIN;NIPAGIN PLAIN;P-HYDROXYBENZOIC ACID METHYL ESTER;RARECHEM AL BF 0098;4-hydroxy-benzoicacimethylester;Abiol;Aseptoform;Benzoic acid, p-hydroxy-, methyl ester
CAS: 99-76-3
MF: C8H8O3
MW: 152.15
EINECS: 202-785-7
Product Categories: Aromatic Esters;Antioxidant;Biochemistry;Color Former & Related Compounds;Developer;Functional Materials;Aromatics;API;Other APIs;Cosmetics
Mol File: 99-76-3.mol
Methylparaben Structure
Methylparaben Chemical Properties
Melting point  125-128 °C(lit.)
Boiling point  298.6 °C
density  1,46g/cm
FEMA  2710
Fp  280°C
storage temp.  0-6°C
Water Solubility  Slightly soluble in water.
FreezingPoint  131℃
Merck  14,6107
BRN  509801
Stability: Stable. Incompatible with strong oxidizing agents, strong bases.
CAS DataBase Reference 99-76-3(CAS DataBase Reference)
NIST Chemistry Reference Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
EPA Substance Registry System Benzoic acid, 4-hydroxy-, methyl ester(99-76-3)
Safety Information
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36-24/25
RIDADR  UN 2769
WGK Germany  1
RTECS  DH2450000
TSCA  Yes
HS Code  29182930
Hazardous Substances Data 99-76-3(Hazardous Substances Data)

Content analysis Method one: determinate according to the content analysis method in "butyl p-hydroxybenzoate (07002)". Per mL 1 mol/L sodium hydroxide is equivalent to the product (C8H8O3) 152.2mg.
Method two: Take 0.1 g (accurate to 1 mg) of the sample previously dried on silica gel for 5 h and move into a 300 ml flask with a glass plug. Plus l mol/L sodium hydroxide 10ml, heated in the water bath for 15min. After cooling, add 0.1mol/L potassium bromate 0.00ml, potassium bromide 5.0g and l mol/L hydrochloric acid 30ml. Put 15min in the dark room after sealing. Add potassium iodide 1 g, shake the flask vigorously, with 0.1mol/L sodium thiosulfate titration, with starch test solution (TS-235) as an indicator. Per ml 0.1mol/L potassium bromate is equivalent to the product (C8H8O3) 25.36mg.
Toxicity ADI 0～10mg/kg(FAO/WHO,2001).
GRAS(FDA,§184．1490，2000).
LD503000mg/kg(Dog, mouth)
Utilization limitation FAO/WHO (1984): Jam, jelly, 1000mg/kg (single or with benzoate, sorbic acid and potassium sorbate).
EEC(1990,mg/kg): For use in pigment solutions, flavor syrups, coffee extracts, frozen drinks, fruit, glucose and soft drinks, pickled fish, salad, sauce, snack food, concentrated soup and so on, limited to GMP; Beer 70; Snack cereals and soup concentrate 175, the same as "07018 p-hydroxybenzoate".
HACSG is listed as a restricted list.
FDA,§184.1490(2000):0.1%.
Chemical properties White needle crystal; Slightly soluble in water, easily soluble in ethanol, ether, acetone and other organic solvents.
Application
Antioxidants.
Antimicrobial agents for medicine and organic synthesis.
Anti-mildew in food, cosmetics and pharmaceutical industries.
As a preservative antiseptic agents in the pharmaceutical industry, also for organic synthesis and food, spices, film and other preservative additives.
Similar products produced by similar production methods, like ethyl p-hydroxybenzoate (paraben B) and propyl p-hydroxybenzoate (Nepalese c), are also disinfectant preservatives.The products are irritating to the skin.
Preparation The drug is esterified with p-hydroxybenzoic acid and methanol. The p-hydroxybenzoic acid was added to excess methanol to dissolve, stirring and adding concentrated sulfuric acid slowly. After heating and refluxing 10h, pour into the water to precipitate crystallization, then washed with water, sodium carbonate solution and water, finally obtain the crude product. Recrystallize from water or 25% ethanol to obtain finished product. The yield was 85%. Raw material consumption (kg/t): p-hydroxybenzoic acid 1200, methanol 1000.